| / English Dictionary |
ACYCLIC
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Having an open chain structure
Synonyms:
acyclic; open-chain
Classified under:
Similar:
aliphatic (having carbon atoms linked in open chains)
Domain category:
chemical science; chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions)
Antonym:
cyclic (of a compound having atoms arranged in a ring structure)
Sense 2
Meaning:
Not cyclic; especially having parts arranged in spirals rather than whorls
Classified under:
Domain category:
botany; phytology (the branch of biology that studies plants)
Antonym:
cyclic (forming a whorl or having parts arranged in a whorl)
Context examples:
An adenoviral vector engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity.
(Adenoviral Vector Encoding HSV Thymidine Kinase, NCI Thesaurus)
Subsequent administration of a synthetic acyclic guanosine analogue, such as valacyclovir (VCV) or ganciclovir (GCV), kills the tumor cells expressing HSV-tk.
(Ad-hCMV-TK, NCI Thesaurus)
An acyclic guanosine analog with activity against herpes simplex virus (HSV).
(Buciclovir, NCI Thesaurus)
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV).
(Cidofovir, NCI Thesaurus)
After subsequent administration of a synthetic acyclic guanosine analogue prodrug like ganciclovir (GCV), expressed HSV-tk phosphorylates and activates the prodrug, which may result in inhibition of DNA synthesis and apoptosis in HSV-tk-expressing cancer cells.
(Ad5.SSTR/TK.RGD, NCI Thesaurus)
Tumor cells expressing HSV-tk are sensitive to synthetic acyclic guanosine analogues.
(Ad-hCMV-TK, NCI Thesaurus)
Adenoviral vector encoding HSV thymidine kinase is transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic acyclic guanosine analogues.
(Adenoviral Vector Encoding HSV Thymidine Kinase, NCI Thesaurus)
This agent, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity.
(Ad-hCMV-TK, NCI Thesaurus)
Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk.
(Adenoviral Vector Encoding HSV Thymidine Kinase, NCI Thesaurus)
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