ADOPTIVE

Pronunciation (US): (GB):

I. (adjective)

Sense 1

Meaning:

Acquired as your own by free choice

Example:

an adoptive country

Synonyms:

adopted; adoptive

Classified under:

Adjectives

Derivation:

adopt (take up and practice as one's own)

Sense 2

Meaning:

Of parents and children; related by adoption

Example:

adoptive parents

Classified under:

Adjectives

Similar:

foster; surrogate (providing or receiving nurture or parental care though not related by blood or legal ties)

Antonym:

biological ((of a parent or child) related by blood; genetically related)

Derivation:

adopt (take into one's family)

Credits

Context examples:

The preserved stemness of T cells — that is, their ability to self-renew indefinitely and respond to stimulation to become cancer-fighting cells — may be what allows adoptive cell transfer therapy to be successful.

(Harnessing T-cell “stemness” could enhance cancer immunotherapy, National Institutes of Health)

APC8015 is a type of vaccine and a type of cellular adoptive immunotherapy.

(APC8015, NCI Dictionary)

This study demonstrates for the first time, that this method of administering TILs, called adoptive T cell transfer immunotherapy, can mediate effective antitumor immune responses against cancers that express the KRAS G12D mutation.

(Cellular immunotherapy targets a common human cancer mutation, NIH)

In adoptive cell transfer, T cells are extracted from a patient’s tumor tissue, expanded to great numbers in the laboratory, and then administered intravenously into the patient along with a T-cell growth factor, with hopes that these cells will return to sites of cancer and eliminate it.

(Oxygen can impair cancer immunotherapy in mice, NIH)

Also called cellular adoptive immunotherapy.

(Adoptive cellular therapy, NCI Dictionary)

Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts.

(Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes, NCI Thesaurus)

Also called adoptive cellular therapy.

(Cellular adoptive immunotherapy, NCI Dictionary)

To prepare CMV pp65-specific cytotoxic T lymphocytes in vitro, dendritic cells (DCs) are pulsed with CMV pp65 epitopes and then used to stimulate and propagate CMV pp65-specific cytotoxic T lymphocytes from peripheral blood mononuclear cells (PBMNCs); the CMV pp65-specific cytotoxic T lymphocyte population is then expanded so as to be sufficient for use in adoptive T lymphocyte therapy.

(Cytomegalovirus pp65-Specific Cytotoxic T Lymphocytes, NCI Thesaurus)

Upon immunoprophylactic adoptive cell therapy infusion with allogeneic cytomegalovirus-specific cytotoxic T lymphocytes, these CTLs may help reconstitute CMV-specific CTL responses in CMV-infected immunocompromised hosts after allogeneic hematopoietic stem cell transplant, thereby potentially preventing the occurrence of CMV viral disease or reducing the amount of antiviral drug therapy.

(Allogeneic Cytomegalovirus-Specific Cytotoxic T lymphocytes, NCI Thesaurus)

However, when the stem-cell-like T cells are removed from the tumor, grown to large numbers in the lab, and then returned to the patient — as they are in a primary immunotherapy strategy called adoptive cell transfer — the stem-cell-like T cells can mature into killer cells that can attack the tumor.