| / English Dictionary |
ALZHEIMER'S DISEASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A progressive form of presenile dementia that is similar to senile dementia except that it usually starts in the 40s or 50s; first symptoms are impaired memory which is followed by impaired thought and speech and finally complete helplessness
Synonyms:
Alzheimer's; Alzheimer's disease; Alzheimers
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("Alzheimer's disease" is a kind of...):
presenile dementia (dementia with onset before the age of 65)
Context examples:
Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease.
(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)
The researchers looked at brains of deceased people with Alzheimer's disease and found evidence of Porphyromonas gingivalis (Pg), a type of bacteria that's associated with gum disease.
(New Link Found between Alzheimer's & Gum Disease Bacteria, The Titi Tudorancea Bulletin)
Genetic variation is involved in both cardiovascular disease and Alzheimer's disease.
(APOE wt Allele, NCI Thesaurus)
APP defects can cause Alzheimer's disease and cerebroarterial amyloidosis.
(APP wt Allele, NCI Thesaurus)
Inhibition of acetylcholinesterase is also used therapeutically to treat Alzheimer's disease, compensating for the loss of cholinergic neurons.
(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)
The gene has also been implicated in the pathogenesis of Alzheimer's disease.
(APPBP2 Gene, NCI Thesaurus)
Test codes of questionnaire questions associated with the Alzheimer's disease cooperative study-clinical global impression of change questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).
(CDISC Questionnaire ADCS-CGIC Test Code Terminology, NCI Thesaurus)
Test names of questionnaire questions associated with the Alzheimer's disease cooperative study-clinical global impression of change questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).
(CDISC Questionnaire ADCS-CGIC Test Name Terminology, NCI Thesaurus)
Criteria for the diagnosis of Alzheimer's disease (AD), proposed in 1984 by the National Institute of Neurological and Communicative Disorders (NINCDS) and the Stroke-Alzheimer's Disease and Related Disorders Association (ADRDA, now the Alzheimer's Association).
(NINCDS-ADRDA Criteria for Alzheimer's Disease, NCI Thesaurus)
Examples of neurodegenerative disorders include Alzheimer's disease and Parkinson's disease.
(Neurodegenerative disorder, NCI Dictionary)
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