| / English Dictionary |
AMITRIPTYLINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
Synonyms:
amitriptyline; amitriptyline hydrochloride; Elavil
Classified under:
Nouns denoting man-made objects
Hypernyms ("amitriptyline" is a kind of...):
tricyclic; tricyclic antidepressant; tricyclic antidepressant drug (an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain)
Context examples:
Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.
(Amitriptyline, NCI Thesaurus)
NDMA receptor antagonists such as amitriptyline and ketamine interfere with the role of NMDA receptors in the process of central sensitization in which NMDA receptors on spinal dorsal horn neurons are activated, resulting in an increase in synaptic efficacy and so an amplification of the response to sensory input.
(Ketamine/Amitriptyline NP-H Cream, NCI Thesaurus)
Also called amitriptyline hydrochloride.
(Amitriptyline, NCI Dictionary)
Also called amitriptyline.
(Amitriptyline hydrochloride, NCI Dictionary)
In addition to activating adenosine A1 receptors and inhibiting the neuronal reuptake of norepinephrine and serotonin, amitriptyline produces antinociceptive effects, which appear to be mediated through the modulation of multiple subtypes of glutamate receptors including the N-methyl D-aspartate (NMDA) receptor.
(Ketamine/Amitriptyline NP-H Cream, NCI Thesaurus)
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