/ English Dictionary

ANTAGONIZE

Pronunciation (US):

(GB):

 I. (verb) 

Sense 1

Meaning:

Provoke the hostility of

Example:

Don't antagonize your boss

Synonyms:

antagonise; antagonize

Classified under:

Verbs of feeling

Hypernyms (to "antagonize" is one way to...):

annoy; bother; chafe; devil; get at; get to; gravel; irritate; nark; nettle; rag; rile; vex (cause annoyance in; disturb, especially by minor irritations)

Sentence frames:

Somebody ----s somebody
Something ----s somebody

Sentence example:

The performance is likely to antagonize Sue

Derivation:

antagonism (an actively expressed feeling of dislike and hostility)

antagonism (a state of deep-seated ill-will)

Sense 2

Meaning:

Act in opposition to

Synonyms:

antagonise; antagonize; counteract

Classified under:

Verbs of political and social activities and events

Hypernyms (to "antagonize" is one way to...):

act; move (perform an action, or work out or perform (an action))

Sentence frame:

Somebody ----s somebody

Credits

 Context examples: 

Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

(Phenothiazine, NCI Thesaurus)

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

(Phosphodiesterase Inhibitor, NLM, Medical Subject Headings)

In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.

(Pimozide, NCI Thesaurus)

Pipendoxifene antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer.

(Pipendoxifene, NCI Thesaurus)

In addition, this agent antagonizes the mu-receptor.

(Pentazocine Hydrochloride, NCI Thesaurus)

A highly modified, fourth generation linear decapeptide with gonadotropin-releasing hormone (GnRH or LHRH) antagonizing properties.

(Ozarelix, NCI Thesaurus)

This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.

(Omeprazole, NCI Thesaurus)

CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs.

(Oocyte Meiosis Pathway, NCI Thesaurus/KEGG)

DIM also antagonizes androgen receptor activity, which may result in diminished cell proliferation and apoptosis in susceptible tumor cell populations.

(Oral Microencapsulated Diindolylmethane, NCI Thesaurus)

Any of the synthetic agents that inhibit or antagonize the biosynthesis or biologic effects of oxytocin by either antagonizing the responsiveness of oxytocin sensitive tissues or competing with its binding sites.

(Oxytocin Antagonist, NCI Thesaurus)

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