| / English Dictionary |
ASPARAGINASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia
Synonyms:
Classified under:
Nouns denoting man-made objects
Hypernyms ("asparaginase" is a kind of...):
antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)
Context examples:
It is a form of the anticancer drug PEG-asparaginase that stays in the body longer.
(Calaspargase Pegol, NCI Dictionary)
Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle.
(asparaginase Erwinia chrysanthemi, NCI Thesaurus)
The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.
(Asparaginase, NCI Thesaurus)
The enzyme asparaginase is used as a cancer treatment through injection.
(Catabolic Pathway for Asparagine and Aspartate, NCI Thesaurus/BIOCARTA)
A regimen consisting of dexamethasone, etoposide, cytarabine and L-asparaginase, used for the treatment of recurrent childhood Non-Hodgkin lymphoma.
(DECAL Regimen, NCI Thesaurus)
Also called Elspar and L-asparaginase.
(Asparaginase, NCI Dictionary)
Also called asparaginase and L-asparaginase.
(Elspar, NCI Dictionary)
Also called Oncaspar and PEG-asparaginase.
(Pegaspargase, NCI Dictionary)
Also called asparaginase Erwinia chrysanthemi.
(Erwinaze, NCI Dictionary)
Also called asparaginase and Elspar.
(L-asparaginase, NCI Dictionary)
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