| / English Dictionary |
ASPARAGINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A crystalline amino acid found in proteins and in many plants (e.g., asparagus)
Classified under:
Hypernyms ("asparagine" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
Context examples:
N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1-Asn.
(N-Glycan Biosynthesis Pathway, NCI Thesaurus/KEGG)
The required asparagine helps to support the rapid growth of malignant cells.
(Catabolic Pathway for Asparagine and Aspartate, NCI Thesaurus/BIOCARTA)
Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle.
(asparaginase Erwinia chrysanthemi, NCI Thesaurus)
It breaks down the amino acid asparagine and may block the growth of cancer cells that need asparagine to grow.
(asparaginase Erwinia chrysanthemi, NCI Dictionary)
Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase.
(Asparaginase, NCI Thesaurus)
Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid.
(Aspartic Acid, NCI Thesaurus)
Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase.
(Calaspargase Pegol, NCI Thesaurus)
EZN-2285 is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.
(Calaspargase Pegol, NCI Dictionary)
Asparaginase is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.
(Oncaspar, NCI Dictionary)
A glycosylation site is an amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications.
(N-Glycosylation Site, NCI Thesaurus)
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