| / English Dictionary |
AUTOIMMUNE DISEASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
Synonyms:
autoimmune disease; autoimmune disorder
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("autoimmune disease" is a kind of...):
disease (an impairment of health or a condition of abnormal functioning)
Meronyms (parts of "autoimmune disease"):
autoimmunity (production of antibodies against the tissues of your own body; produces autoimmune disease or hypersensitivity reactions)
Hyponyms (each of the following is a kind of "autoimmune disease"):
myasthenia; myasthenia gravis (a chronic progressive disease characterized by chronic fatigue and muscular weakness (especially in the face and neck); caused by a deficiency of acetylcholine at the neuromuscular junctions)
disseminated multiple sclerosis; disseminated sclerosis; MS; multiple sclerosis (a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers)
autoimmune diabetes; growth-onset diabetes; IDDM; insulin-dependent diabetes mellitus; juvenile-onset diabetes; juvenile diabetes; ketoacidosis-prone diabetes; ketosis-prone diabetes; type I diabetes (severe diabetes mellitus with an early onset; characterized by polyuria and excessive thirst and increased appetite and weight loss and episodic ketoacidosis; diet and insulin injections are required to control the disease)
exophthalmic goiter; Graves' disease (exophthalmos occurring in association with goiter; hyperthyroidism with protrusion of the eyeballs)
atrophic arthritis; rheumatism; rheumatoid arthritis (a chronic autoimmune disease with inflammation of the joints and marked deformities; something (possibly a virus) triggers an attack on the synovium by the immune system, which releases cytokines that stimulate an inflammatory reaction that can lead to the destruction of all components of the joint)
ankylosing spondylitis; Marie-Strumpell disease; rheumatoid spondylitis (a chronic form of spondylitis primarily in males and marked by impaired mobility of the spine; sometimes leads to ankylosis)
discoid lupus erythematosus; DLE (a chronic skin disease occurring primarily in women between the ages of 20 and 40; characterized by an eruption of red lesions over the cheeks and bridge of the nose)
Hashimoto's disease (autoimmune disorder of the thyroid gland; most common in middle-aged women)
LE; lupus erythematosus (a chronic inflammatory collagen disease affecting connective tissue (skin or joints))
pemphigus (a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane)
dermatosclerosis; scleroderma (an autoimmune disease that affects the blood vessels and connective tissue; fibrous connective tissue is deposited in the skin)
idiopathic thrombocytopenic purpura; purpura hemorrhagica; thrombocytopenic purpura; Werlhof's disease (purpura associated with a reduction in circulating blood platelets which can result from a variety of factors)
Context examples:
A syndrome of immologically mediated tissue damage occurring following allogeneic transplant and may affect multiple organs with manifestations similar to autoimmune diseases.
(Chronic Graft Versus Host Disease, NCI Thesaurus)
Certain HLA-DQ protein variants are associated with susceptibility to insulin-dependent diabetes mellitus and several autoimmune diseases.
(HLA-DQ Antigen, NCI Thesaurus)
It is used to treat some autoimmune diseases, and is being studied as a treatment for graft-versus-host disease.
(Hydroxychloroquine, NCI Dictionary)
Mutations in the gene are associated with vitiligo-associated multiple autoimmune disease susceptibility 1.
(NLRP1 wt Allele, NCI Thesaurus)
An injury, infection, or autoimmune disease can cause it.
(Myositis, NIH: National Institute of Neurological Disorders and Stroke)
This agent maybe used in T-cell related autoimmune diseases including psoriasis, rheumatoid arthritis and Crohn s disease and T-cell cancers
(Peldesine, NCI Thesaurus)
Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases.
(PI3K delta/gamma Inhibitor IPI-145, NCI Thesaurus)
Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and in inflammatory and autoimmune diseases.
(PI3K Delta/Gamma Inhibitor RP6530, NCI Thesaurus)
Myasthenia gravis is an autoimmune disease.
(Myasthenia Gravis, NIH: National Institute of Neurological Disorders and Stroke)
No one knows what causes MS. It may be an autoimmune disease, which happens when your immune system attacks healthy cells in your body by mistake.
(Multiple Sclerosis, NIH: National Institute of Neurological Disorders and Stroke)
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