| / English Dictionary |
AUTOLOGOUS
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Derived from organisms of the selfsame individual
Example:
autologous blood donation
Classified under:
Antonym:
heterologous (derived from organisms of a different but related species)
homologous (corresponding or similar in position or structure or function or characteristics; especially derived from an organism of the same species)
Context examples:
A stem cell transplant may be autologous (a patient’s own blood cells saved earlier), allogeneic (blood cells donated by someone else), or syngeneic (blood cells donated by an identical twin).
(Peripheral blood stem cell transplant, NCI Dictionary)
Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 reactive TCR-transduced autologous PBLs bind to NY-ESO-1-overexpressing tumor cells.
(NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBL, NCI Thesaurus)
A cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide.
(Mutant p53 Peptide Pulsed Dendritic Cell Vaccine, NCI Thesaurus)
Autologous vaccination with these altered dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for NA17, resulting in decreased tumor growth.
(NA17 Peptide (Amino acid sequence VLPDVFIRCV), NCI Thesaurus)
Exosomes derived from autologous maturing dendritic cells (DCs) are pulsed with HLA-DP04-restricted MAGE-3, and HLA-A02-restricted peptides NY-ESO-1, MAGE-1, MAGE-3, and MART-1.
(NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes, NCI Thesaurus)
Upon administration, AFP peptide-pulsed autologous dendritic cell vaccine may stimulate anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against AFP-expressing cancer cells, resulting in tumor cell lysis.
(Alpha-fetoprotein Peptide-Pulsed Autologous Dendritic Cell Vaccine, NCI Thesaurus)
A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma.
(AMD 3100, NCI Dictionary)
A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a recombinant adenovirus encoding p53 peptide, with potential immunomodulating activity.
(Adenovirus-p53 Transduced Dendritic Cell Vaccine, NCI Thesaurus)
Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity.
(Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells, NCI Thesaurus)
Autologous peripheral blood mononuclear cells (PBMC) are collected and separated into monocytes and lymphocytes.
(AAV-DC-CTL Tumor Cell Targeting Therapy, NCI Thesaurus)
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