| / English Dictionary |
BETA-ADRENERGIC RECEPTOR
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Receptors postulated to exist on nerve cell membranes of the sympathetic nervous system in order to explain the specificity of certain agents that affect only some sympathetic activities (such as vasodilation and increased heart beat)
Synonyms:
beta-adrenergic receptor; beta-adrenoceptor; beta receptor
Classified under:
Hypernyms ("beta-adrenergic receptor" is a kind of...):
receptor (a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response)
Holonyms ("beta-adrenergic receptor" is a part of...):
sympathetic nervous system (originates in the thoracic regions of the spinal cord; opposes physiological effects of the parasympathetic: reduces digestive secretions; speeds the heart; contracts blood vessels)
Context examples:
The sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.
(Isoproterenol Sulfate, NCI Thesaurus)
Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol.
(Beta Adrenergic Receptor, NCI Thesaurus)
This allele, which encodes beta-adrenergic receptor kinase 2 protein, is involved in the phosphorylation of the activated form of the beta-adrenergic and related G-protein-coupled receptors.
(ADRBK2 wt Allele, NCI Thesaurus)
Exaprolol competitively binds to and blocks beta-adrenergic receptors in the heart and vascular smooth muscle, thereby causing negative chronotropic and inotropic effects leading to a reduction in cardiac output.
(Exaprolol, NCI Thesaurus)
In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands.
(Amiodarone, NCI Thesaurus)
This allele, which encodes beta-arrestin-1 protein, plays a role in the desensitization of beta-adrenergic receptor signaling.
(ARRB1 wt Allele, NCI Thesaurus)
Beta-adrenergic receptor kinase 1 (689 aa, ~80 kDa) is encoded by the human ADRBK1 gene.
(Beta-Adrenergic Receptor Kinase 1, NCI Thesaurus)
Carvedilol is a racemic mixture; the S(-) enantiomer non-selectively binds to and blocks beta-adrenergic receptors, exerting negative inotropic and chronotropic effects, leading to a reduction in cardiac output.
(Carvedilol Phosphate Extended-Release Capsule, NCI Thesaurus)
The S enantiomer of carvedilol nonselectively binds to and blocks beta-adrenergic receptors, thereby exerting negative inotropic and chronotropic effects, and leading to a reduction in cardiac output.
(Carvedilol phosphate, NCI Thesaurus)
This allele, which encodes beta-adrenergic receptor kinase 1 protein, plays a role in the phosphorylation of the activated form of the beta-adrenergic and related G-protein-coupled receptors.
(ADRBK1 wt Allele, NCI Thesaurus)
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