| / English Dictionary |
BETA-LACTAMASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
Synonyms:
beta-lactamase; penicillinase
Classified under:
Hypernyms ("beta-lactamase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Context examples:
A combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor tazobactam with antibacterial activity.
(Piperacillin-tazobactam, NCI Thesaurus)
Clavulanic acid is a beta-lactamase inhibitor, which prevents the beta-lactamase enzyme destroying penicillin; it is already used as a medicine to treat kidney infections during pregnancy.
(Widely-available antibiotics could be used in the treatment of ‘superbug’ MRSA, University of Cambridge)
Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.
(Ampicillin, NCI Thesaurus)
A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity.
(Ampicillin Sodium/Sulbactam Sodium, NCI Thesaurus)
This species is indole positive, but lipase, catalase, urease and nitrate negative, hydrolyzes esculin and gelatin, and is beta-lactamase positive thus resistant to penicillin G, vancomycin, ceftizoxime, cefotetan.
(Bacteroides nordii, NCI Thesaurus)
This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
(Aztreonam, NCI Thesaurus)
This agent undergoes a color change as its amide bond is hydrolyzed by beta-lactamase, making it useful as a reagent in beta-lactamase activity studies.
(Nitrocefin, NCI Thesaurus)
The sodium salt form of cefoperazone and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.
(Cefoperazone Sodium, NCI Thesaurus)
A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium.
(Amoxicillin-clavulanate potassium, NCI Thesaurus)
A fixed combination of Amoxicillin and Clavulanic Acid, which inhibits beta-lactamase, a bacterial enzyme that inactivates amoxicillin.
(Amoxicillin-Clavulanic Acid, NCI Thesaurus)
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