| / English Dictionary |
BIOSYNTHETIC
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Of or relating to biosynthesis
Classified under:
Relational adjectives (pertainyms)
Pertainym:
biosynthesis (production of a chemical compound by a living organism)
Derivation:
biosynthesis (production of a chemical compound by a living organism)
Context examples:
As the stereoisomer of 5,10-dideazatetrahydrofolate, lometrexol selectively inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis and leading to an inhibition of tumor cell proliferation.
(Lometrexol Sodium, NCI Thesaurus)
As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.
(Lometrexol, NCI Thesaurus)
A common reaction in the biosynthetic pathway is C-P bond forming reaction from phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy) catalyzed by PEP phosphomutase. 2-Aminoethylphosphonate (AEP) is the most abundant C-P compound in the natural world.
(Aminophosphonate Metabolism Pathway, NCI Thesaurus/KEGG)
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