| / English Dictionary |
CASCADES
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A mountain range in the northwestern United States extending through Washington and Oregon and northern California; a part of the Coast Range
Synonyms:
Cascade Mountains; Cascade Range; Cascades
Classified under:
Nouns denoting natural objects (not man-made)
Instance hypernyms:
chain; chain of mountains; mountain chain; mountain range; range; range of mountains (a series of hills or mountains)
Meronyms (parts of "Cascades"):
Mount Saint Helens; Mount St. Helens; Mt. St. Helens (an active volcano in the Cascade Range in southwestern Washington; erupted violently in 1980 after 123 years of inactivity)
Adams; Mount Adams (a mountain peak in southwestern Washington in the Cascade Range (12,307 feet high))
Mount Rainier; Mount Tacoma; Mt. Rainier; Rainier (a mountain peak in central Washington; highest peak in the Cascade Range; (14,410 feet high))
Holonyms ("Cascades" is a part of...):
Northwest; northwestern United States (the northwestern region of the United States)
Coast Mountains; Coast Range (a string of mountain ranges along the Pacific coast of North America from southeastern Alaska to Lower California)
II. (verb)
Sense 1
Present simple (third person singular) of the verb cascade
Context examples:
Mannosylerythritol lipid activates protein kinase signal cascades, resulting in cell differentiation, condensation of chromatin, DNA fragmentation, G1 phase cell-cycle arrest, and apoptosis of tumor cells.
(Mannosylerythritol Lipid, NCI Thesaurus)
The keratinocyte differentiation cascades also provide for detailed study of the functions of individual PKC isoforms and it is interesting to note the contrasting functions of the PKC isoforms in this process.
(Keratinocyte Differentiation Pathway, NCI Thesaurus/BIOCARTA)
As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades.
(ETS Family Gene, NCI Thesaurus)
In addition, this agent inhibits both the extrinsic and intrinsic coagulation cascades, preventing blood clot formation.
(Factor VIIa Inhibitor PCI-27483, NCI Thesaurus)
These cascades illustrate that ceramide can be a growth stimulus or proapoptotic signal.
(Ceramide Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)
Reversible binding of calcium with proteins often supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades.
(Calcium Binding Protein, NCI Thesaurus)
The G-protein coupled receptor (GPCR) family transduces extracellular signals across the plasma membrane, activating cellular responses through a variety of second messenger cascades (see PKA and PKC signaling pathways).
(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)
Activated caspase 8 stimulates apoptosis via two parallel cascades: it directly cleaves and activates caspase-3, and it cleaves Bid (a Bcl-2 family protein).
(DR3 and DR4/5 Mediated Apoptosis Pathway, NCI Thesaurus/BIOCARTA)
Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis.
(Complement Degradation Process, NCI Thesaurus)
Conatumumab mimics the activity of native TRAIL, binding to and activating TR-2, thereby activating caspase cascades and inducing tumor cell apoptosis.
(Conatumumab, NCI Thesaurus)
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