| / English Dictionary |
CASPASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Any of a group of proteases that mediate apoptosis
Classified under:
Hypernyms ("caspase" is a kind of...):
peptidase; protease; proteinase; proteolytic enzyme (any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis)
Context examples:
Acadesine-induced apoptosis also appears to require cytochrome c release from mitochondria and caspase activation and is p53-independent.
(Acadesine, NCI Thesaurus)
In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the drug binding domain and induces caspase 9 expression.
(Allogeneic T-Lymphocytes BPX-501, NCI Thesaurus)
Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases.
(Androstane Steroid HE3235, NCI Thesaurus)
Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors.
(AKT Signaling Pathway, NCI Thesaurus/BIOCARTA)
This may result in the activation of c-Jun-NH2-kinase (JNK) and ultimately apoptosis via Bcl2 suppression and caspase-3 activation.
(Ad-REIC/DKK3 Vaccine, NCI Thesaurus)
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others that are caspase independent.
(AIF Pathway, NCI Thesaurus/BIOCARTA)
This gene is involved in pro-apoptotic regulation through caspase interaction.
(APAF1 Gene, NCI Thesaurus)
The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors.
(Alzheimer's Disease Pathway KEGG, NCI Thesaurus/KEGG)
Activated Apaf-1 activates caspase-9 and the rest of the caspase cascade.
(Apoptosis DNA Damage Pathway, NCI Thesaurus/BIOCARTA)
This allele, which encodes apoptotic protease-activating factor 1, plays a role in the mediation of caspase cleavage and the propagation of apoptosis.
(APAF1 wt Allele, NCI Thesaurus)
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