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CD4
I. (noun)
Sense 1
Meaning:
A glycoprotein that is found primarily on the surface of helper T cells
Example:
CD4 is a receptor for HIV in humans
Synonyms:
CD4; cluster of differentiation 4
Classified under:
Hypernyms ("CD4" is a kind of...):
glycoprotein (a conjugated protein having a carbohydrate component)
Context examples:
The activated DCs present the NY-ESO-1 antigen to Th1 CD4 T-lymphocytes.
(NY-ESO-1/GLA-SE Vaccine ID-G305, NCI Thesaurus)
In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS.
(Nevirapine, NCI Thesaurus)
It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking.
(Oncogene LCK, NCI Thesaurus)
CD28 has been widely characterized as a costimulatory receptor for CD4+ T cells.
(OX40 Signaling Pathway, NCI Thesaurus/BIOCARTA)
Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR) to suppress antibody production by B-cells.
(Murine T-Lymphocytes, Suppressor-Inducer, NLM, Medical Subject Headings)
A chimeric murine-human anti-CD4 monoclonal antibody that down regulates T-helper-inducer function.
(Monoclonal Antibody M-T412, NCI Thesaurus)
The determination of the ratio of CD4 cells compared to CD8 cells present in a sample.
(CD4 Cell to CD8 Cell Ratio Measurement, NCI Thesaurus)
Present peptides to CD4+ T cells.
(MHC Class II Gene, NCI Thesaurus)
Probiotic Lactobacillus strains have been shown to protect against gastrointestinal and urogenital infections, to moderate diarrheal episodes, and to increase CD4 T-lymphocyte counts.
(Micronutrient-Fortified Probiotic Yogurt, NCI Thesaurus)
Any monoclonal antibody directed against the cell surface glycoprotein CD4, regardless of the antibody type.
(Anti-CD4 Monoclonal Antibody, NCI Thesaurus)
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