| / English Dictionary |
CELL-MEDIATED IMMUNE RESPONSE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An immune response (chiefly against viral or fungal invasions or transplanted tissue) that involves T cells
Classified under:
Nouns denoting acts or actions
Hypernyms ("cell-mediated immune response" is a kind of...):
immune reaction; immune response; immunologic response (a bodily defense reaction that recognizes an invading substance (an antigen: such as a virus or fungus or bacteria or transplanted organ) and produces antibodies specific against that antigen)
Context examples:
This may restore immune function through the activation both of T-cells and cell-mediated immune responses against PD-1 overexpressing tumor cells.
(Anti-PD-1 Monoclonal Antibody AMP-514, NCI Thesaurus)
This allele, which encodes B-lymphocyte antigen CD19 protein, plays a role in the modulation of B-cell-mediated immune responses.
(CD19 wt Allele, NCI Thesaurus)
Anti-PD-L1 monoclonal antibody MPDL3280A binds to PD-L1, blocking its binding to and activation of its receptor, PD-1 (programmed death 1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation.
(Anti-PD-L1 Monoclonal Antibody MPDL3280A, NCI Thesaurus)
Th1 cells produce interferon gamma, interleukin (IL)-2, and tumor necrosis factor-beta and promote a cell-mediated immune response.
(Delayed-Type Hypersensitivity, NCI Thesaurus)
This protein may be involved in B cell-mediated immune responses.
(Fc Receptor-Like Protein 4, NCI Thesaurus)
Introducing these melanoma tumor-reactive autologous tumor infiltrating lymphocytes back into the same patient may enhance a cytotoxic T-cell-mediated immune response against the melanoma cancer cells.
(Melanoma Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte, NCI Thesaurus)
Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands PD-L1 and PD-L2, resulting in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens.
(Nivolumab, NCI Thesaurus)
Upon oral ingestion, Maitaki mushroom extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thereby amplifying both innate and T cell-mediated immune responses against cancer cells.
(Maitake Mushroom Extract, NCI Thesaurus)
Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.
(HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine, NCI Thesaurus)
Upon administration, lambrolizumab binds to PD-1, an inhibitory signaling receptor expressed on the surface of activated T cells, and blocks the binding to and activation of PD-1 by its ligands, which results in the activation of T-cell-mediated immune responses against tumor cells.
(Lambrolizumab, NCI Thesaurus)
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