| / English Dictionary |
CENTROSOME
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Small region of cytoplasm adjacent to the nucleus; contains the centrioles and serves to organize the microtubules
Synonyms:
Classified under:
Hypernyms ("centrosome" is a kind of...):
cytol; cytoplasm (the protoplasm of a cell excluding the nucleus; is full of proteins that control cell metabolism)
Derivation:
centrosomic (of or relating to a centrosome)
Context examples:
This protein is involved in centrosome localization.
(Ninein, NCI Thesaurus)
It has been demonstrated that PKA-RIIa dissociates and redistributes from centrosomes at mitosis.
(Centrosome Pathway, NCI Thesaurus/BIOCARTA)
This allele, which encodes serine/threonine-protein kinase 6 protein, plays a regulatory role in the G2 and M phases of the cell cycle via involvement in mitotic entry, centrosome duplication and spindle assembly.
(AURKA wt Allele, NCI Thesaurus)
Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules.
(Cell Cycle Progression Pathway, NCI Thesaurus/BIOCARTA)
Widely expressed like TUBG1 by human TUBG2 Gene (Tubulin Family), 451-aa 51-kDa Gamma Tubulin 2 is an essential component of microtubule organizing centers such as spindle poles or centrosomes, with 97.3% sequence identity to TUBG1, and likely involved in minus-end nucleation of microtubule assembly.
(Gamma Tubulin 2, NCI Thesaurus)
Expressed most in prophase through metaphase, during maximal microtubule assembly from centrosomes, by human TUBG1 Gene (Tubulin Family), ubiquitous and highly conserved 451-aa 51-kDa Gamma Tubulin 1 is a component of microtubule organizing centers such as spindle poles or pericentriolar microtubule-nucleating material of centrosomes that interacts with GCP2 and GCP3 and may be involved in minus-end nucleation of microtubule assembly.
(Gamma Tubulin 1, NCI Thesaurus)
Ubiquitous or widely expressed 51-kDa conserved Gamma-Tubulins (Tubulin Family) constitute a major essential component of microtubule organizing centers such as spindle poles or centrosomes that are likely involved in minus-end nucleation of microtubule assembly.
(Gamma-Tubulin, NCI Thesaurus)
Mitotic enzymes regulate various mitotic events including centrosome separation, mitotic spindle assembly, chromosome alignment, phosphorylation of tubulin and cell-cycle regulators, and interaction with mitotic kinesins; other roles include facilitating the progression through and the exit from mitosis as well as regulating cytokinesis.
(Mitotic Enzyme Modulator, NCI Thesaurus)
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