| / English Dictionary |
CHROMATID
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
One of two identical strands into which a chromosome splits during mitosis
Classified under:
Hypernyms ("chromatid" is a kind of...):
fibril; filament; strand (a very slender natural or synthetic fiber)
Holonyms ("chromatid" is a part of...):
chromosome (a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order)
Context examples:
At anaphase of meiosis II or mitosis when the centromeres divide and the sister chromatids separate each chromatid becomes a chromosome.
(Chromatid, NCI Thesaurus)
AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.
(KSP Inhibitor AZD4877, NCI Thesaurus)
Microtubule Stabilization consists of activities involved in maintenance of filamentous tubes of variable length in the cytoskeleton composed primarily of conserved alpha, beta, and gamma tubulin that support movement of chromosomes or chromatids during mitosis and meiosis; and give shape, structure, and organization to the cytoplasm and to a cell.
(Microtubule Stabilization, NCI Thesaurus)
Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis.
(Aurora B Serine/Threonine Kinase Inhibitor TAK-901, NCI Thesaurus)
At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell.
(Mitotic Sister Chromatid Cohesion, NCI Thesaurus)
The chromatids are held together at the centromere.
(Chromatid, NLM, Medical Subject Headings)
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