/ English Dictionary

CROSS-LINK

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

A side bond that links two adjacent chains of atoms in a complex molecule

Synonyms:

cross-link; cross-linkage

Classified under:

Nouns denoting natural phenomena

Hypernyms ("cross-link" is a kind of...):

bond; chemical bond (an electrical force linking atoms)

Derivation:

cross-link (join by creating covalent bonds (of adjacent chains of a polymer or protein))

 II. (verb) 

Sense 1

Meaning:

Join by creating covalent bonds (of adjacent chains of a polymer or protein)

Classified under:

Verbs of touching, hitting, tying, digging

Hypernyms (to "cross-link" is one way to...):

conjoin; join (make contact or come together)

Sentence frame:

Somebody ----s something

Derivation:

cross-link; cross-linkage (a side bond that links two adjacent chains of atoms in a complex molecule)

Credits

 Context examples: 

A pegylated, cross-linked, humanized divalent-Fab' antibody fragment directed against vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic and antitumor activities.

(Pegylated Anti-GFR Antibody Fragment, NCI Thesaurus)

Piperacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

(Piperacillin Anhydrous, NCI Thesaurus)

A mustard compound that gets converted to an active mustard alkylating agent at a tumor site, causing DNA cross-linking.

(Mustard Prodrug, NCI Thesaurus)

Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity.

(Morpholinodoxorubicin, NCI Thesaurus)

Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.

(Mitomycin Antineoplastic Antibiotic, NCI Thesaurus)

Bioreduced mitomycin B generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.

(Mitomycin B, NCI Thesaurus)

These cross-links result in apoptosis and cell growth inhibition.

(BP-Cx1-Platinum Complex BP-C1, NCI Thesaurus)

Carzinophilin forms interstrand DNA cross-links, thereby inhibiting DNA synthesis.

(Carzinophilin, NCI Thesaurus)

Acetate salt of Ametantrone, a topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA.

(Ametantrone Acetate, NCI Thesaurus)

Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.

(Antineoplastic Alkylating Agent, NCI Thesaurus)

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