| / English Dictionary |
CYCLOOXYGENASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
Synonyms:
Classified under:
Hypernyms ("cyclooxygenase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Hyponyms (each of the following is a kind of "cyclooxygenase"):
Cox-1; cyclooxygenase-1 (an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys)
Cox-2; cyclooxygenase-2 (an enzyme that makes prostaglandins that cause inflammation and pain and fever)
Context examples:
They also inhibit a variety of pro-inflammatory enzymes, such as cyclooxygenase 1 (COX-1) and COX-2, block the formation of reactive-oxygen species and neutralize free radicals.
(Olive Oil Extract/Curcumin-based Capsule, NCI Thesaurus)
Naproxen sodium reversibly and competitively inhibits cyclooxygenases (COX), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins.
(Naproxen Sodium, NCI Thesaurus)
It is a type of nonsteroidal anti-inflammatory drug (NSAID) and a type of cyclooxygenase inhibitor.
(Naprosyn, NCI Dictionary)
Any agent that inhibits prostaglandin G/H synthase (cyclooxygenase or COX), an enzyme that catalyzes the production of prostanoids, including prostaglandins, prostacyclin and thromboxane, from arachidonic acid.
(Cyclooxygenase inhibitor, NCI Thesaurus)
Cyclooxygenase-2 inhibitors are being studied in the prevention of colon polyps, and as anticancer drugs.
(Cyclooxygenase-2 inhibitor, NCI Dictionary)
Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis.
(Bardoxolone, NCI Thesaurus)
Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG).
(Bromfenac, NCI Thesaurus)
Ciclopirox exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
(Ciclopirox Olamine Lotion, NCI Thesaurus)
In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
(Ciclopirox, NCI Thesaurus)
Also called cyclooxygenase-2 and prostaglandin-endoperoxide synthase 2.
(COX-2, NCI Dictionary)
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