| / English Dictionary |
CYTOTOXICITY
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The degree to which something is toxic to living cells
Classified under:
Nouns denoting quantities and units of measure
Hypernyms ("cytotoxicity" is a kind of...):
toxicity (the degree to which something is poisonous)
Context examples:
Monoclonal antibody HuHMFG1 stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing MUC1, resulting in a decrease in tumor burden.
(Monoclonal Antibody HuHMFG1, NCI Thesaurus)
Monoclonal antibody L6 binds to the L6 antigen, a cell surface glycoprotein overexpressed in many carcinomas, and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against L6-expressing tumor cells.
(Monoclonal Antibody L6, NCI Thesaurus)
MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types.
(Mycophenolate mofetil, NCI Thesaurus)
MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides.
(Mycophenolate, NCI Thesaurus)
Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity.
(Mycophenolate Sodium, NCI Thesaurus)
Natural cytotoxicity triggering receptor 2 (276 aa, ~30 kDa) is encoded by the human NCR2 gene.
(Natural Cytotoxicity Triggering Receptor 2, NCI Thesaurus)
Natural cytotoxicity triggering receptor 3 (201 aa, ~22 kDa) is encoded by the human NCR3 gene.
(Natural Cytotoxicity Triggering Receptor 3, NCI Thesaurus)
These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity.
(Murine Natural Killer Cells, NCI Thesaurus)
Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity.
(Morpholinodoxorubicin, NCI Thesaurus)
This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils.
(Monoclonal Antibody Lym-1, NCI Thesaurus)
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