| / English Dictionary |
DAMAGING
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Designed or tending to discredit, especially without positive or helpful suggestions
Example:
negative criticism
Synonyms:
damaging; negative
Classified under:
Similar:
destructive (causing destruction or much damage)
Sense 2
Meaning:
(sometimes followed by 'to') causing harm or injury
Example:
the reporter's coverage resulted in prejudicial publicity for the defendant
Synonyms:
damaging; detrimental; prejudicial; prejudicious
Classified under:
Similar:
harmful (causing or capable of causing harm)
II. (verb)
Sense 1
-ing form of the verb damage
Context examples:
A disorder characterized by an enduring pattern of unstable self-image and mood together with volatile interpersonal relationships, self-damaging impulsivity, recurrent suicidal threats or gestures and/or self-mutilating behavior.
(Borderline personality disorder, NCI Thesaurus)
Inhibition of cell cycle checkpoint/DNA repair enzymes may enhance the cytotoxicity of DNA damaging agents and dissipate tumor cell resistance to chemotherapy and radiation therapy.
(Cell Cycle Checkpoint/DNA Repair Antagonist IC83, NCI Thesaurus)
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases.
(Class II AP Endonuclease, NCI Thesaurus)
These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence.
(DNA Damage, NCI Thesaurus)
Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane.
(Clotrimazole, NCI Thesaurus)
Glaucoma happens when pressure builds up in the eye, damaging the main nerve.
(Diabetic Eye Problems, NIH: National Institute of Diabetes and Digestive and Kidney Diseases)
It kills cancer cells by damaging their DNA and stopping them from dividing.
(Cisplatin, NCI Dictionary)
Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death.
(Chlorozotocin, NCI Thesaurus)
This agent may enhance the cytotoxicity of DNA-damaging agents.
(Checkpoint Kinase Inhibitor AZD7762, NCI Thesaurus)
Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components.
(Econazole Nitrate, NCI Thesaurus)
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