| / English Dictionary |
DEAMINATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Removal of the amino radical from an amino acid or other amino compound
Synonyms:
deamination; deaminization
Classified under:
Nouns denoting natural processes
Hypernyms ("deamination" is a kind of...):
chemical action; chemical change; chemical process ((chemistry) any process determined by the atomic and molecular composition and structure of the substances involved)
Derivation:
deaminate (remove the amino radical (usually by hydrolysis) from an amino compound; to perform deamination)
Context examples:
Compared to cytarabine, elacytarabine shows increased cellular uptake and retention, resulting in increased activation by deoxycytidine kinase to cytarabine triphosphate, decreased deamination and deactivation by deoxycytidine deaminase, and increased inhibition of DNA synthesis.
(Elacytarabine, NCI Thesaurus)
Transamination or deamination of glutamate produces a-ketoglutarate which feeds into the citric acid cycle.
(Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway, NCI Thesaurus/BIOCARTA)
Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.
(Nucleotide Analogue GS 9219, NCI Thesaurus)
This species is motile, indole positive, lysine decarboxylase, ornithine decarboxylase, and catalase positive, and negative for Vosges-Proskauer, citrate utilization, urea hydrolysis, phenylalanine deamination, arginine dihydrolase, growth in KCN and fermentation of lactose, sucrose, myo-inositol, D-sorbitol, raffinose and alpha-methyl-D-glucose.
(Escherichia fergusonii, NCI Thesaurus)
Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain.
(Phenelzine Sulfate, NCI Thesaurus)
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