DEGRADATION

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Changing to a lower state (a less respected state)

Synonyms:

debasement; degradation

Classified under:

Nouns denoting acts or actions

Hypernyms ("degradation" is a kind of...):

change of state (the act of changing something into something different in essential characteristics)

Hyponyms (each of the following is a kind of "degradation"):

dehumanisation; dehumanization (the act of degrading people with respect to their best qualities)

animalisation; animalization; brutalisation; brutalization (an act that makes people cruel or lacking normal human qualities)

barbarisation; barbarization (an act that makes people primitive and uncivilized)

bastardisation; bastardization (an act that debases or corrupts)

corruption; subversion (destroying someone's (or some group's) honesty or loyalty; undermining moral integrity)

demoralisation; demoralization (destroying the moral basis for a doctrine or policy)

constipation; deadening; impairment; stultification (the act of making something futile and useless (as by routine))

popularisation; popularization; vulgarisation; vulgarization (the act of making something attractive to the general public)

profanation (degradation of something worthy of respect; cheapening)

abasement; humiliation (depriving one of self-esteem)

vulgarisation; vulgarization (the act of rendering something coarse and unrefined)

Derivation:

degrade (lower the grade of something; reduce its worth)

degrade (reduce in worth or character, usually verbally)

Sense 2

Meaning:

A low or downcast state

Example:

each confession brought her into an attitude of abasement

Synonyms:

abasement; abjection; degradation

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("degradation" is a kind of...):

humiliation (state of disgrace or loss of self-respect)

Hyponyms (each of the following is a kind of "degradation"):

decadence; decadency; degeneracy; degeneration (the state of being degenerate in mental or moral qualities)

depth ((usually plural) a low moral state)

Derivation:

degrade (lower the grade of something; reduce its worth)

degrade (reduce in worth or character, usually verbally)

Credits

Context examples:

Activation of MR leads to increased expression of Sgk-1, which phosphorylates Nedd4-2, an ubiquitin-ligase which targets ENAC to proteasomal degradation.

(Aldosterone-Regulated Sodium Reabsorption Pathway, NCI Thesaurus/KEGG)

In the absence of Wnt signaling, GSK3 is active and phosphorylates b-catenin resulting in its degradation by ubiquitin-mediated proteolysis.

(ALK Pathway, NCI Thesaurus/BIOCARTA)

Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

(Anthracycline Antineoplastic Antibiotic, NCI Thesaurus)

A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10.

(Antineoplaston AS2-1, NCI Thesaurus)

ARE elements are involved in directing RNA to rapid degradation and deadenylation.

(AU RNA Binding Protein, NCI Thesaurus/LocusLink)

In addition, binding of Sym004 to EGFRs causes EGFR internalization and degradation.

(Anti-EGFR Monoclonal Antibody Mixture Sym004, NCI Thesaurus)

This results in an inhibition of extracellular matrix protein degradation and, potentially, the inhibition of angiogenesis, tumor growth, invasion, and metastasis.

(Anti-MMP-9 Monoclonal Antibody GS-5745, NCI Thesaurus)

Acetylcholine is removed from synapses through degradation by the enzyme acetylcholinesterase.

(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)

This gene plays a role in degradation of proteoglycans and fibronectin.

(MMP10 Gene, NCI Thesaurus)

Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.