| / English Dictionary |
DEGRADED
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Lowered in value
Example:
a debased currency
Synonyms:
Classified under:
Similar:
low (less than normal in degree or intensity or amount)
Sense 2
Meaning:
Unrestrained by convention or morality
Example:
fast women
Synonyms:
debauched; degenerate; degraded; dissipated; dissolute; fast; libertine; profligate; riotous
Classified under:
Similar:
immoral (deliberately violating accepted principles of right and wrong)
II. (verb)
Sense 1
Past simple / past participle of the verb degrade
Context examples:
Human beings, their feelings and passions, would indeed be degraded if such a wretch as I felt pride.
(Frankenstein, by Mary Wollstonecraft Shelley)
An organelle formed by the fusion of a phagosome with the lysosome, where the contents of the phagosome are degraded.
(Phagolysosome, NCI Thesaurus)
The natives were Cucama Indians, an amiable but degraded race, with mental powers hardly superior to the average Londoner.
(The Lost World, by Sir Arthur Conan Doyle)
I felt—yes, idiot that I am—I felt degraded.
(Jane Eyre, by Charlotte Brontë)
Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.
(PA700 Regulatory Module, NCI Thesaurus)
Degraded Ras peptides have been shown to stimulate immunogenic response.
(Mutated Ras Peptide, NCI Thesaurus)
Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases.
(Monoubiquitination, NCI Thesaurus)
Finally, the ubiquitinated, deglycosylated protein is degraded by the proteasome.
(Endoplasmic Reticulum Degradation Pathway, NCI Thesaurus/BIOCARTA)
Skp2 expression is cyclical, increasing in the S/G2 transition as E2F-1 is degraded.
(E2F1 Degradation Pathway, NCI Thesaurus/BIOCARTA)
Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle.
(Cyclin Regulation of Cell Cycle Pathway, NCI Thesaurus/BIOCARTA)
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