/ English Dictionary

DENATURE

Pronunciation (US):

(GB):

 I. (verb) 

Sense 1

Meaning:

Make (alcohol) unfit for drinking without impairing usefulness for other purposes

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Sense 2

Meaning:

Modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Derivation:

denaturant (any substance that serves as a denaturing agent)

Sense 3

Meaning:

Add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb

Classified under:

Verbs of size, temperature change, intensifying, etc.

Hypernyms (to "denature" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Derivation:

denaturant (any substance that serves as a denaturing agent)

Credits

 Context examples: 

Next, the crosslinks are broken, the proteins are removed and the purified DNA is amplified, denatured and labeled with a fluorescent tag.

(ChIP-On-Chip, NCI Thesaurus)

RNA extracted from a sample was denatured and separated by slab gel electrophoresis, then blotted on to a nitrocellulose or nylon sheet and hybridized with labeled DNA or RNA that is complementary to the desired RNA, whose presence is subsequently indicated by autoradiography or other visualization techniques.

(Northern Blotting, NCI Thesaurus)

Scientists particularly discovered two physical-chemical barriers that prevent the presence of living organisms in ponds: the abundance of chaotropic magnesium salts (an agent that breaks hydrogen bridges and denatures biomolecules) and the simultaneous confluence of hypersaline, hyperacid and high-temperature conditions.

(Place discovered on earth with no microbial life, The Titi Tudorancea Bulletin)

The dsDNA molecules are heat denatured, and then quickly cooled.

(Conformation Dependent Mutation Detection, NCI Thesaurus/OSP)

Anti-denatured collagen recombinant monoclonal antibody TRC093 binds to multiple epitopes on denatured collagens, inhibiting proteolytic collagen-mediated signaling in the extracellular matrix (ECM) that is important to tumor angiogenesis, tumor growth, and metastasis.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)

The labeled, denatured DNA fragments are applied to a DNA microarray where they can hybridize to their complementary DNA sequence.

(ChIP-On-Chip, NCI Thesaurus)

Base mutations will often result in altered conformations, with altered mobilities, which can be visualized following separation in non-denaturing gels.

(Conformation Dependent Mutation Detection, NCI Thesaurus/OSP)

The epitopes on denatured collagen bound by this antibody are considered cryptic because, in vivo, they are accessible only on the subendothelial basement membrane of tumors or in normal tissues undergoing neovascularization.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)

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