| / English Dictionary |
DEPOLARIZATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A loss of polarity or polarization
Synonyms:
depolarisation; depolarization
Classified under:
Nouns denoting natural phenomena
Hypernyms ("depolarization" is a kind of...):
change (the result of alteration or modification)
Derivation:
depolarize (eliminate the polarization of)
Context examples:
Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation.
(Nimodipine, NCI Thesaurus)
At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
(Mepivacaine, NCI Thesaurus)
Undersensing manifests as failure to sense appropriate cardiac depolarizations that cannot be resolved with reprogramming.
(Cardiac Device Undersensing, NCI Thesaurus/ACC)
Inhibition of sodium channels prevents the depolarization of nerve cell membranes and inhibits subsequent propagation of impulses along the course of the nerve, thereby limiting the excitation of nerve endings.
(Dibucaine, NCI Thesaurus)
Issue associated with the inability of device and/or device components to achieve successful depolarization and contraction of a cardiac chamber caused by a pacemaker output pulse.
(Capturing Issue Medical Device Problem, Food and Drug Administration)
This process is involved in intracellular signaling and in maintaining depolarization of the heart.
(Calcium Signaling, NCI Thesaurus)
Acetylcholine diffuses across the cleft and binds to muscle acetylcholine receptors, causing depolarization and an action potential that travels throughout the length of the muscle cell triggering muscle contraction.
(Botulin Pathway, NCI Thesaurus/BIOCARTA)
This may lead to mitochondrial membrane depolarization and reactive oxygen species (ROS) generation.
(Anti-HLA-DR Monoclonal Antibody IMMU-114, NCI Thesaurus)
This allele, which encodes voltage-dependent T-type calcium channel subunit alpha-1G protein, plays a role in both calcium transport and membrane depolarization.
(CACNA1G wt Allele, NCI Thesaurus)
Ethotoin influences synaptic transmission by altering sodium and calcium ion influx across neuronal membranes in the repolarization, depolarization, and membrane stability phase and interferes with the calcium uptake in presynaptic terminals.
(Ethotoin, NCI Thesaurus)
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