ENDONUCLEASE

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

A nuclease that cleaves nucleic acids at interior bonds and so produces fragments of various sizes

Classified under:

Hypernyms ("endonuclease" is a kind of...):

nuclease (general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units)

Hyponyms (each of the following is a kind of "endonuclease"):

restriction endonuclease; restriction enzyme; restriction nuclease (any of the enzymes that cut nucleic acid at specific restriction sites and produce restriction fragments; obtained from bacteria (where they cripple viral invaders); used in recombinant DNA technology)

Credits

Context examples:

DNA excision repair protein ERCC-1, encoded by the ERCC1 gene, is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair.

(DNA Excision Repair Protein ERCC-1, NCI Thesaurus)

Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity.

(Dicer Pathway, NCI Thesaurus/BIOCARTA)

Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site.

(Class II AP Endonuclease, NCI Thesaurus)

Another apoptosis activated protease is endonuclease G, EndoG.

(Apoptotic DNA Fragmentation Pathway, NCI Thesaurus/BIOCARTA)

The two incisions made during NER are catalyzed by separate DNA endonucleases.

(DNA Excision Repair Protein ERCC-4, NCI Thesaurus)

Endonuclease 8-like 3 (605 aa, ~68 kDa) is encoded by the human NEIL3 gene.

(Endonuclease 8-Like 3, NCI Thesaurus)

Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.

(Base Excision Repair, NCI Thesaurus)

It is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site.

(DNA Excision Repair Protein ERCC-5, NCI Thesaurus)

In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, resulting in un-repaired DNA strand breaks which may induce apoptosis.

(Lucanthone, NCI Thesaurus)