| / English Dictionary |
EPITOPE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The site on the surface of an antigen molecule to which an antibody attaches itself
Synonyms:
antigenic determinant; determinant; epitope
Classified under:
Hypernyms ("epitope" is a kind of...):
site; situation (physical position in relation to the surroundings)
Domain category:
immunology (the branch of medical science that studies the body's immune system)
Holonyms ("epitope" is a part of...):
antigen (any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies))
Context examples:
Pan-DR epitope (PADRE) 965.10 is a helper peptide.
(PADRE 965.10, NCI Thesaurus)
Upon administration, the multi-epitope FR alpha peptide vaccine may induce a cytotoxic T-lymphocyte (CTL) response against FR alpha-overexpressing tumor cells.
(Multi-epitope Folate Receptor Alpha Peptide Vaccine, NCI Thesaurus)
A monovalent Fab fragment of the mouse monoclonal antibody (MoAb) 96.5, raised against an epitope from human melanoma-associated cell surface marker p97.
(Monoclonal Antibody 96.5 F(ab), NCI Thesaurus)
A murine and humanized monoclonal antibody that targets epitopes of epithelial glycoprotein mucin (MUC-1) on breast cancer surfaces.
(Monoclonal Antibody BrE-3, NCI Thesaurus)
A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity.
(Monoclonal Antibody RAV12, NCI Thesaurus)
The CA6 epitope is found on a variety of solid tumors, including breast, ovarian, cervical, lung and pancreatic tumors.
(Anti-CA6-DM4 Immunoconjugate SAR566658, NCI Thesaurus)
A humanized monoclonal antibody recognizing the tumor-specific epitope of mucin-1 (TA-MUC1), with potential antineoplastic activity.
(Anti-TA-MUC1 Monoclonal Antibody PankoMab, NCI Thesaurus)
The determination of the amount of aggrecan chondroitin sulfate epitope 846 present in a sample.
(Aggrecan Chondroitin Sulfate Epitope 846 Measurement, NCI Thesaurus)
ALVAC-CEA (6D)-B7.1 vaccine expresses both a highly immunogenic analogue (6D) of the immunodominant epitope of carcinoembryonic antigen (CEA) and B7.1 (also known as CD80), the natural ligand for the T-cell antigen CD28.
(ALVAC-CEA (6D)-B7.1 Vaccine, NCI Thesaurus)
PADRE is a helper T-lymphocyte epitope that is able to augment the magnitude and duration of the cytotoxic T-lymphocyte (CTL) response.
(Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine, NCI Thesaurus)
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