| / English Dictionary |
ER
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A room in a hospital or clinic staffed and equipped to provide emergency care to persons requiring immediate medical treatment
Synonyms:
Classified under:
Nouns denoting man-made objects
Hypernyms ("ER" is a kind of...):
hospital room (a room in a hospital for the care of patients)
Sense 2
Meaning:
A trivalent metallic element of the rare earth group; occurs with yttrium
Synonyms:
atomic number 68; Er; erbium
Classified under:
Hypernyms ("Er" is a kind of...):
metal; metallic element (any of several chemical elements that are usually shiny solids that conduct heat or electricity and can be formed into sheets etc.)
Holonyms ("Er" is a substance of...):
fergusonite (a dark mineral consisting of oxides of yttrium and erbium and tantalum and other minerals)
gadolinite; ytterbite (a mineral that is a source of rare earths; consists of silicates of iron and beryllium and cerium and yttrium and erbium)
Context examples:
Pipendoxifene antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer.
(Pipendoxifene, NCI Thesaurus)
Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death.
(Parkinson's Disease Pathway BioCarta, NCI Thesaurus/BIOCARTA)
Furthermore, agonist receptors activate calcium channels of the endoplasmic reticulum (ER) via phospholipase C and inositol 1,4,5-trisphosphate.
(Nitric Oxide Pathway, NCI Thesaurus/BIOCARTA)
The outer nuclear membrane is continuous with the rough endoplasmic reticulum (ER) and has ribosomes attached.
(Nuclear Outer Membrane, NCI Thesaurus)
Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress.
(Apoptosis Pathway, NCI Thesaurus/KEGG)
Cytochrome P450 2D5 is a rat liver ER membrane-bound heme-thiolate monooxygenase, involved in an NADPH-dependent electron transport pathway that oxidizes various compounds, including steroids, fatty acids, and xenobiotics.
(Cytochrome P450 2D5, NCI Thesaurus)
Don't forget you're to tell Mr.—er—Haythorne who I am.
(Love of Life and Other Stories, by Jack London)
APP in the ER is cleaved at residue 17 by alpha-secretase protease activity encoded by ADAM-10 and TACE.
(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)
FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
(Alzheimer's Disease Pathway KEGG, NCI Thesaurus/KEGG)
—er—quarrelsome, and harsh measures are necessary.
(The Sea-Wolf, by Jack London)
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