FAMILIAL

Pronunciation (US): (GB):

I. (adjective)

Sense 1

Meaning:

Occurring among members of a family usually by heredity

Example:

genetically transmitted features

Synonyms:

familial; genetic; hereditary; inherited; transmissible; transmitted

Classified under:

Adjectives

Similar:

heritable; inheritable (capable of being inherited)

Derivation:

family (a person having kinship with another or others)

Sense 2

Meaning:

Relating to or having the characteristics of a family

Example:

familial aggregation

Classified under:

Relational adjectives (pertainyms)

Pertainym:

family (primary social group; parents and children)

Derivation:

family (primary social group; parents and children)

Credits

Context examples:

Mutations in the gene are associated with familial juvenile nephronophthisis type 1, Senior-Loken syndrome type 1, and Joubert syndrome type 4.

(NPHP1 wt Allele, NCI Thesaurus)

The RAGE gene is associated with a number of neurological disorders including Parkinson's disease, familial amyloidotic polyneuropathy, and vasculitic neuropathy.

(MOK wt Allele, NCI Thesaurus)

Mutation of the gene is associated with familial erythrocytosis type 3.

(EGLN1 wt Allele, NCI Thesaurus)

Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM.

(Dilated Cardiomyopathy Pathway, NCI Thesaurus/KEGG)

This rearrangement is associated with familial renal cell carcinoma.

(DIRC3/HSPBAP1 Fusion Gene, NCI Thesaurus)

A sporadic or familial pheochromocytoma that is confined to the adrenal gland and does not have any metastatic potential.

(Benign Adrenal Gland Pheochromocytoma, NCI Thesaurus)

The neoplastic C-cell hyperplasia is associated with familial medullary thyroid gland carcinoma and multiple endocrine neoplasia type II and IIB.

(C-Cell Hyperplasia, NCI Thesaurus)

ABTA has a special funding program for scientists sponsored by NIH, and sponsors a research study focusing on familial brain tumors.

(American Brain Tumor Association, NCI Thesaurus)

Mutations in presenilin-1 have been genetically associated with familial forms of Alzheimer's disease, further supporting the role of APP processing the development of the disease.

(Amyloid Beta-Peptide Pathway, NCI Thesaurus/BIOCARTA)

Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy.