| / English Dictionary |
FAS
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A congenital medical condition in which body deformation occurs or facial development or mental ability is impaired because the mother drinks alcohol during pregnancy
Synonyms:
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("FAS" is a kind of...):
syndrome (a pattern of symptoms indicative of some disease)
Context examples:
The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and is present in the TNF receptor, FAS, and several downstream signaling molecules.
(Death Domain, NCI Thesaurus)
Also called: FAS
(Fetal Alcohol Spectrum Disorders, Centers for Disease Control and Prevention)
Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS.
(Caspase Cascade Pathway, NCI Thesaurus/BIOCARTA)
Fas induces apoptosis through two pathways, one mediated by the protein Daxx.
(HSP27 Regulation Pathway, NCI Thesaurus/BIOCARTA)
Binding of FAS to oligomerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade.
(Fas Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)
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