| / English Dictionary |
FENTANYL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Trade names of a narcotic analgesic that can be inhaled and that acts on the central nervous system and may become addictive; used as a veterinary anesthetic and with other drugs before, during, and after surgery; also used as a nonlethal gas to incapacitate people in hostage situations; also abused as a recreational drug
Synonyms:
Classified under:
Nouns denoting man-made objects
Hypernyms ("Fentanyl" is a kind of...):
analgesic; anodyne; pain pill; painkiller (a medicine used to relieve pain)
opiate (a narcotic drug that contains opium or an opium derivative)
Context examples:
Many medical providers turn to opioids, such as morphine or fentanyl, for moderate to severe post-operative pain relief, but these often come with side effects that can interfere with recovery, including respiratory depression, inhibition of gut motility and constipation, nausea and vomiting.
(Chemical from cactus-like plant shows promise in controlling surgical pain, while leaving touch and coordination intact, National Institutes of Health)
A terminology subset for NCPDP that contains concepts that qualify the strength and strength unit of measure associated with the prescribed product (e.g., Amoxicillin 250 mg Tablet, Albuterol HFA 17 gram Inhaler, Albuterol HFA 90 mcg [implied per actuation] Inhaler, Cefaclor 250 MG/5ML Suspension, Fentanyl 12 mcg/hr Patch , Epinephrine 0.3 mg [implied per dose] Auto-Injector, Timolol 0.25% Ophthalmic Drops, Sprintec 28 Day Pack, Hydrocortisone 1% Ointment).
(NCPDP Strength Form Terminology, NCI Thesaurus)
Fentanyl selectively binds to and activates mu-opioid receptors in the central nervous system (CNS), mimicking the effects of endogenous opioids.
(Fentanyl Citrate Buccal Tablet, NCI Thesaurus)
After rapid sublingual transmucosal absorption, the active ingredient fentanyl selectively binds to and activates mu-opioid receptors in the central nervous system (CNS), mimicking the effects of endogenous opiates.
(Fentanyl Citrate Pectin-Based Nasal Spray, NCI Thesaurus)
The citrate salt of fentanyl, a synthetic opioid related to the phenylpiperidines with analgesic and anesthetic properties.
(Fentanyl citrate, NCI Thesaurus)
A form of the drug fentanyl that is sprayed under the tongue and then absorbed into the blood.
(Fentanyl sublingual spray, NCI Dictionary)
Fentanyl selectively binds to and activates mu-opioid receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opiates.
(Fentanyl Buccal Soluble Film, NCI Thesaurus)
A nasal spray containing a phosphate-buffered solution of the citrate salt form of fentanyl, a short-acting, synthetic, lipophilic anilidopiperidine opioid, with analgesic activity.
(Fentanyl Citrate-containing Nasal Spray, NCI Thesaurus)
The analgesic effect of fentanyl is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability.
(Fentanyl, NCI Thesaurus)
Upon topical administration, fentanyl diffuses from the transdermal patch through the skin, is transported via the systemic circulation, and selectively binds to the mu-receptor in the central nervous system (CNS), mimicking the effects of endogenous opiates.
(Fentanyl Matrix Transdermal Patch, NCI Thesaurus)
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