| / English Dictionary |
GASTRIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Polypeptide hormone secreted by the mucous lining of the stomach; when peptides and amino acids are present in the small intestine the secretion of gastric acid is stimulated
Classified under:
Hypernyms ("gastrin" is a kind of...):
gastrointestinal hormone; GI hormones (hormones that affect gastrointestinal functioning)
Context examples:
ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell.
(Enterochromaffin-Like Cell, NLM, Medical Subject Headings)
An agent that antagonizes bombesin, an endogenous neurotransmitter found in many animals, and affects smooth muscle, gastrin secretion, and renal function.
(Bombesin Antagonist, NCI Thesaurus)
An immunotoxin composed of the hormone gastrin linked to diphtheria toxin.
(G17DT Immunogen, NCI Thesaurus)
Endocrine cells found in the pyloric gland mucosa (antral mucosa) of the stomach and responsible for the secretion of gastrin.
(G-Cell, NLM, Medical Subject Headings)
This allele, which encodes gastrin/cholecystokinin type B receptor protein, plays a role in modulating the regulatory peptides of the brain and gastrointestinal tract.
(CCKBR wt Allele, NCI Thesaurus)
Levels of bombesin, also known as gastrin releasing peptide (GRP), are elevated in lung and thyroid cancers, where the substance acts as an autocrine growth factor.
(MoAb Bombesin (DTPA), NCI Thesaurus)
It produces gastrin and it may be associated with Zollinger-Ellison syndrome.
(Gastric Gastrin-Producing Neuroendocrine Tumor, NCI Thesaurus)
Gastrin (101 aa, ~11 kDa) is encoded by the human GAST gene.
(Gastrin, NCI Thesaurus)
Upon administration of YF476, this agent selectively binds to and blocks the CCKBR, thereby preventing the binding of gastrin and cholecystokinin.
(Cholecystokinin B Receptor Antagonist YF476, NCI Thesaurus)
Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone.
(Octreotide, NCI Thesaurus)
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