GLYCOL

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Any of a class of alcohols having 2 hydroxyl groups in each molecule

Synonyms:

dihydric alcohol; diol; glycol

Classified under:

Nouns denoting substances

Hypernyms ("glycol" is a kind of...):

alcohol (any of a series of volatile hydroxyl compounds that are made from hydrocarbons by distillation)

Sense 2

Meaning:

A sweet but poisonous syrupy liquid used as an antifreeze and solvent

Synonyms:

ethanediol; ethylene glycol; glycol

Classified under:

Nouns denoting substances

Hypernyms ("glycol" is a kind of...):

antifreeze (a liquid added to the water in a cooling system to lower its freezing point)

Credits

Context examples:

A formulation of polyethylene glycol (PEG)-modified liposomes encapsulating the semisynthetic derivative of camptothecin irinotecan, with antineoplastic activity.

(Pegylated Liposomal Irinotecan, NCI Thesaurus)

The propylene glycol form of cefatrizine, a semi-synthetic, first-generation cephalosporin with strong activity against gram-positive cocci except enterococci.

(Cefatrizine Propylene Glycolate, NCI Thesaurus)

A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity.

(Certolizumab Pegol, NCI Thesaurus)

A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent.

(Pegylated Interferon Alfa, NCI Thesaurus)

A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent.

(Peginterferon alfa-2a, NCI Thesaurus)

A formulation of polyethylene glycol (PEG)-encapsulated irinotecan with antineoplastic activity.

(Pegylated Irinotecan, NCI Thesaurus)

A proprietary 44-nucleotide L-stereoisomer RNA oligonucleotide conjugated to a 40 kDa polyethylene glycol (PEG) that targets hepcidin with potential anti-anemic activity.

(PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94, NCI Thesaurus)

The sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity.

(Pegaptanib Sodium, NCI Thesaurus)

A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent.

(Peginterferon alfa-2b, NCI Thesaurus)

Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life.