| / English Dictionary |
GOBLET CELL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An epithelial cell that secretes mucous
Classified under:
Hypernyms ("goblet cell" is a kind of...):
epithelial cell (one of the closely packed cells forming the epithelium)
Context examples:
It is characterized by the presence of microvacuolated columnar cells that are admixed with small numbers of goblet cells.
(Colorectal Microvesicular Hyperplastic Polyp, NCI Thesaurus)
Encoded by human SLC26A3 Gene (SLC26A/SulP Transporter Family), 764-aa 85-kDa Chloride Anion Exchanger is a sulfate/chloride/bicarbonate transmembrane glycoprotein exchange transporter containing 1 STAS domain and localized in lower intestinal columnar epithelial apical membranes and some goblet cells.
(Chloride Anion Exchanger, NCI Thesaurus)
There is loss of nuclear polarity, dystrophic goblet cells (goblet cells with nuclei oriented towards the lumen and mucinous cytoplasm oriented toward the basement membrane), mitoses which may occasionally be abnormal, nuclear irregularities and prominent (macro) nucleoli.
(Mouse Pancreatic Intraepithelial Neoplasia-3, NCI Thesaurus/MMHCC)
MUC2, a secretory or gel forming glycoprotein expressed predominantly in goblet cells of the gastrointestinal and respiratory tracts, is overexpressed as an aberrant or deglycosylated form in various tumors such as gastric carcinomas and some hormone-refractory prostate cancers.
(MUC-2-KLH Vaccine, NCI Thesaurus)
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