| / English Dictionary |
HIGHLY
| Pronunciation (US): |  | (GB): | |
I. (adverb)
Sense 1
Meaning:
In a high position or level or rank
Example:
details known by only a few highly placed persons
Classified under:
Pertainym:
high (standing above others in quality or position)
Sense 2
Meaning:
To a high degree or extent; favorably or with much respect
Example:
extremely interesting
Synonyms:
extremely; highly
Classified under:
Pertainym:
high (greater than normal in degree or intensity or amount)
Sense 3
Meaning:
At a high rate or wage
Example:
highly paid workers
Classified under:
Adverbs
Context examples:
Tell her that you think very highly of the understanding of women.
(Northanger Abbey, by Jane Austen)
Please, ma'am, could I inquire if this highly instructive and charming institution is a new one?
(Little Women, by Louisa May Alcott)
The expression of DLL4 is highly restricted to the vascular endothelium; DLL4/Notch signaling is required for the development of functional tumor blood vessels.
(Anti-DLL4 Monoclonal Antibody MEDI0639, NCI Thesaurus)
The glycoprotein endoglin is a transforming growth factor beta-1 (TGF beta-1) accessory receptor that is highly expressed on tumor vessel endothelial cells and appears to be essential for angiogenesis.
(Anti-Endoglin Chimeric Monoclonal Antibody TRC105, NCI Thesaurus)
IGF1/2 ligands stimulate cell proliferation, enable oncogenic transformation, and suppress apoptosis; IGF1/2 signaling has been highly implicated in tumorigenesis and metastasis.
(Anti-IGF1/2 Monoclonal Antibody MEDI-573, NCI Thesaurus)
The linkage system in SGN-LIV1A is highly stable in plasma, resulting in cytotoxic specificity against LIV-1-positive cells.
(Anti-LIV-1 Monoclonal Antibody-MMAE Conjugate SGN-LIV1A, NCI Thesaurus)
A cancer vaccine consisting of ALVAC, a highly attenuated poxvirus strain derived from the canarypox virus, encoding for the tumor associated antigen (TAA) carcinoembryonic antigen (CEA), with potential antineoplastic activity.
(ALVAC-CEA vaccine, NCI Thesaurus)
ALVAC-CEA (6D)-B7.1 vaccine expresses both a highly immunogenic analogue (6D) of the immunodominant epitope of carcinoembryonic antigen (CEA) and B7.1 (also known as CD80), the natural ligand for the T-cell antigen CD28.
(ALVAC-CEA (6D)-B7.1 Vaccine, NCI Thesaurus)
A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas.
(Aggressive NK-Cell Leukemia, NCI Thesaurus)
A second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity.
(Alisertib, NCI Thesaurus)
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