| / English Dictionary |
HOMOLOGY
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I. (noun)
Sense 1
Meaning:
The quality of being similar or corresponding in position or value or structure or function
Classified under:
Nouns denoting attributes of people and objects
Hypernyms ("homology" is a kind of...):
similarity (the quality of being similar)
Derivation:
homologic; homological (similar in evolutionary origin but not in function)
homologize (make homologous)
homologize (be homologous)
homologous (corresponding or similar in position or structure or function or characteristics; especially derived from an organism of the same species)
Context examples:
PLC d1 has a pleckstrin homology (PH) domain that binds to PIP2 in the membrane with an affinity of 1.7 mM.
(Phospholipid Associated Cell Signaling Pathway, NCI Thesaurus/BIOCARTA)
The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein.
(NY-ESO-B, NCI Thesaurus)
TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains.
(Non-Receptor Tyrosine Kinase 1, NCI Thesaurus)
Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the PTB and SH2 domains.
(Neuronal SHC, NCI Thesaurus)
Encoded by single copy human NPY Gene (NPY Family), 97-aa 11-kDa (precursor) secreted Neuropeptide Y is a 36-aa peptide neuromodulator with sequence homology to peptide YY and PNP.
(Neuropeptide Y, NCI Thesaurus)
Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene.
(DNA Mismatch Repair Protein PMS1, NCI Thesaurus)
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1).
(ERBB2 Signaling Pathway, NCI Thesaurus/BIOCARTA)
The BCL-2 Gene Family encodes proteins that contain Bcl-2 homology (BH) domains (1, 2, 3, or 4), involved in interactions among apoptotic protein factors that participate in programmed cell death.
(BCL-2 Gene Family, NCI Thesaurus)
CD8 Antigen Beta Polypeptide 1 glycoprotein exhibits significant homology to Ig variable light chains and mediates efficient cell-cell interactions in the immune system, as an alpha/alpha or alpha/beta coreceptor with T-cell receptor.
(CD8 Antigen, Beta Polypeptide 1, NCI Thesaurus)
This nuclear protein is a DNA-binding bZIP transcription factor that, as a homodimer, recognizes common motifs in both the promoter (CCAAT sequence) and enhancer (core homology sequence) regions of genes.
(CCAAT/Enhancer Binding Protein Alpha, NCI Thesaurus)
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