| / English Dictionary |
HYBRIDIZATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
(genetics) the act of mixing different species or varieties of animals or plants and thus to produce hybrids
Synonyms:
cross; crossbreeding; crossing; hybridisation; hybridization; hybridizing; interbreeding
Classified under:
Nouns denoting acts or actions
Hypernyms ("hybridization" is a kind of...):
conjugation; coupling; mating; pairing; sexual union; union (the act of pairing a male and female for reproductive purposes)
Domain category:
genetic science; genetics (the branch of biology that studies heredity and variation in organisms)
Hyponyms (each of the following is a kind of "hybridization"):
dihybrid cross (hybridization using two traits with two alleles each)
monohybrid cross (hybridization using a single trait with two alleles (as in Mendel's experiments with garden peas))
reciprocal; reciprocal cross (hybridization involving a pair of crosses that reverse the sexes associated with each genotype)
test-cross; testcross (a cross between an organism whose genotype for a certain trait is unknown and an organism that is homozygous recessive for that trait so the unknown genotype can be determined from that of the offspring)
Derivation:
hybridize (breed animals or plants using parents of different races and varieties)
Context examples:
After hybridization occurs, the microarray chip is imaged and the captured fluorescence signals from the array are normalized and subjected to statistical analysis.
(ChIP-On-Chip, NCI Thesaurus)
Includes karyotyping, fluorescence in situ hybridization, and chromosome painting.
(Chromosome Rearrangement Detection, NCI Thesaurus/OSP)
Also called fluorescence in situ hybridization.
(FISH, NCI Dictionary)
The hybridization signal of a specific sequence is compared to that of a reference sequence, usually one known to be present once per haploid genome.
(Gene Amplification or Deletion Detection, NCI Thesaurus)
Amber Rice, an evolutionary biologist at Lehigh, studies hybridization — when separate species come into contact and mate — to better understand how species originate and how the existing, parent species are maintained.
(Scent brings songbirds to the yard, National Science Foundation)
Applications include Northern and Southern blots, in situ hybridization techniques, and diagnostic tests.
(DNA Probes, NCI Thesaurus)
Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
(Chromosome Banding, NLM, Medical Subject Headings)
Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes.
(Comparative Genomic Hybridization, NCI Thesaurus)
The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of chromosomes, i.e. spectral or color karyotyping.
(Chromosome Painting, NCI Thesaurus)
The Resource provides biochemical, hybridization, and scanning services, genome-wide SNP analysis and resequencing analysis, consultation in experimental design and data mining.
(Microarray Shared Resource, NCI Thesaurus)
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