| / English Dictionary |
IG
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response
Synonyms:
Ig; immune gamma globulin; immune globulin; immune serum globulin; immunoglobulin
Classified under:
Hypernyms ("Ig" is a kind of...):
gamma globulin; human gamma globulin (a plasma protein containing the immunoglobulins that are responsible for immune responses)
antibody (any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response)
Hyponyms (each of the following is a kind of "Ig"):
IgA; immunoglobulin A (one of the most common of the five major classes of immunoglobulins; the chief antibody in the membranes of the gastrointestinal and respiratory tracts)
IgD; immunoglobulin D (one of the five major classes of immunoglobulins; present in blood serum in small amounts)
IgE; immunoglobulin E (one of the five major classes of immunoglobulins; present primarily in the skin and mucous membranes)
IgG; immunoglobulin G (one of the five major classes of immunoglobulins; the main antibody defense against bacteria)
IgM; immunoglobulin M (one of the five major classes of immunoglobulins; involved in fighting blood infections and in triggering production of immunoglobulin G)
tetanus immune globulin; tetanus immunoglobulin (sterile solution of globulins derived from the blood plasma of a person who has been immunized for tetanus; provides short-term immunization against tetanus in cases of possible exposure to the tetanus bacillus)
Context examples:
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules.
(B Cell Receptor Complex Signaling Pathway, NCI Thesaurus/BIOCARTA)
Containing only the antigen-binding fragment of the Ig molecule, MoAb MX35 F(ab')2 offers the advantages of smaller size and lower cross-reactivity compared to complete antibodies.
(Monoclonal Antibody MX35 F(ab')2, NCI Thesaurus)
A dietary supplement consisting of bovine colostrum, containing high titers of immunoglobulins (Igs), with immunostimulating and anti-infective activities.
(Hyperimmune Bovine Colostrum, NCI Thesaurus)
Two alternatively spliced FGFR2 gene products, KGFR and BEK, vary in sequence within the third extracellular Ig loop, which influence ligand-binding characteristics.
(Fibroblast Growth Factor Receptor 2, NCI Thesaurus)
PD-1, a transmembrane protein in the Ig superfamily, negatively regulates T-cell activation and effector function when activated by its ligands, and plays an important role in tumor evasion from host immunity.
(Anti-PD-1 Monoclonal Antibody AMP-514, NCI Thesaurus)
PD-1, a transmembrane protein of Ig superfamily, negatively regulates T-cell activation and effector function when activated by its ligands, and plays an important role in tumor evasion from host immunity.
(Anti-PD-1 Fusion Protein AMP-224, NCI Thesaurus)
CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF.
(CTCF Pathway, NCI Thesaurus/BIOCARTA)
Pathologic Ab-Ig Proteins are immunoglobulin-related (IgA, IgD, IgE, IgG, IgM antibody) glycoproteins characteristically found in patients with multiple myeloma, infectious diseases, rheumatoid arthritis and other connective tissue diseases, or systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
(Pathologic Ab-Ig Protein, NCI Thesaurus)
Vertebrate and invertebrate cell adhesion molecules in the nervous system are usually cell surface membrane proteins with multiple N-terminal Ig domains, followed by several fibronectin type III repeats, and either a transmembrane intracellular domain or a C-terminal glycophosphatidylinositol-linked membrane anchor.
(Neuronal Cell Adhesion Molecule, NCI Thesaurus)
Nivolumab binds to and blocks the activation of PD-1, an Ig superfamily transmembrane protein, by its ligands PD-L1 and PD-L2, resulting in the activation of T-cells and cell-mediated immune responses against tumor cells or pathogens.
(Nivolumab, NCI Thesaurus)
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