| / English Dictionary |
IGE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
One of the five major classes of immunoglobulins; present primarily in the skin and mucous membranes
Synonyms:
IgE; immunoglobulin E
Classified under:
Hypernyms ("IgE" is a kind of...):
Ig; immune gamma globulin; immune globulin; immune serum globulin; immunoglobulin (a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response)
Hyponyms (each of the following is a kind of "IgE"):
reagin (an immunoglobulin E that is formed as an antibody against allergens (such as pollen); attaches to cell membranes causing the release of histamine and other substances responsible for the local inflammation characteristic of an allergy)
Context examples:
They usually develop in the ileocoecal lymph nodes, and about 60% of them synthesis monoclonal immunoglobulins (Bence-Jones proteins) of IgG1 (35%), IgE (36%) or IgA classes.
(LOU/C, Rat Strain, NCI Thesaurus)
Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
(Interleukin-13, NCI Thesaurus/LocusLink)
This gene is involved in the production of IgE and B cell differentiation.
(FCER2 Gene, NCI Thesaurus)
GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.
(GRB2-Associated Binding Protein 2, NCI Thesaurus)
Activated Th2 cells stimulate B cells to produce IgE antibodies in response to IL-4 and IL-13.
(Asthma Pathway, NCI Thesaurus/KEGG)
Immunoglobulin E (IgE) sensitisation to allergens has been shown to be associated with increased risk of allergic diseases and asthma.
(New Approach to Predict Respiratory Allergy in Early Childhood, The Titi Tudorancea Bulletin)
While non-allergic mice lacked Tfh13 cells, allergic mice had both Tfh13 cells and high-affinity IgE.
(Scientists discover immune cell subtype in mice that drives allergic reactions, National Institutes of Health)
The blood marker they identified is a type of antibody (immunoglobulin or IgE) that is specific to the alpha-Gal allergen.
(Researchers have found a link between allergen in red meat and heart disease, National Institutes of Health)
Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms.
(Atopy, NCI Thesaurus)
It is characterized by decreased levels of IgG, IgA, and IgE, and normal or increased levels of IgM.
(Immunodeficiency With Hyper-IgM, NCI Thesaurus)
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