INACTIVATION

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Breaking up a military unit (by transfers or discharges)

Synonyms:

deactivation; inactivation

Classified under:

Nouns denoting acts or actions

Hypernyms ("inactivation" is a kind of...):

discharge; dismissal; dismission; firing; liberation; release; sack; sacking (the termination of someone's employment (leaving them free to depart))

Domain category:

armed forces; armed services; military; military machine; war machine (the military forces of a nation)

Derivation:

inactivate (release from military service or remove from the active list of military service)

Sense 2

Meaning:

The process of rendering inactive

Example:

thermal inactivation of serum samples

Classified under:

Nouns denoting natural processes

Hypernyms ("inactivation" is a kind of...):

action; activity; natural action; natural process (a process existing in or produced by nature (rather than by the intent of human beings))

Antonym:

activation (stimulation of activity in an organism or chemical)

Derivation:

inactivate (make inactive)

Credits

Context examples:

This allele, which encodes transcriptional repressor CTCFL protein, is involved in both gene regulation and X-chromosome inactivation.

(CTCFL wt Allele, NCI Thesaurus)

Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC.

(CTCF Pathway, NCI Thesaurus/BIOCARTA)

This protein can substitute for histone H2A in the nucleosomal complex and plays a role in transcriptional repression and X chromosome inactivation.

(Core Histone Macro-H2A, NCI Thesaurus)

This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis.

(Carbenicillin, NCI Thesaurus)

A gene whose loss or inactivation is associated with one or more types of cancer.

(Candidate Tumor Suppressor Gene, NCI Thesaurus)

Because of the increase in steric bulk around the platinum center, there is a relative reduction in the inactivation of picoplatin by thiol-containing species such as glutathione and metallothionein in comparison to cisplatin.

(Oral Picoplatin, NCI Thesaurus)

Moreover, melanoma development is strongly associated with inactivation of the p16INK4a/CDK4,6/pRb and p14ARF/HMD2/p53 tumor suppressor pathways.

(Melanoma Pathway, NCI Thesaurus/KEGG)

This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein.

(Paclitaxel liposome, NCI Thesaurus)

Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signaling pathway.

(Pancreatic Cancer Pathway, NCI Thesaurus/KEGG)

This protein plays a role in the metabolism of steroid hormones and the inactivation of androgens.