INNATE IMMUNITY

Pronunciation (US): (GB):

I. (noun)

Sense 1

Meaning:

Immunity to disease that occurs as part of an individual's natural biologic makeup

Synonyms:

innate immunity; natural immunity

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("innate immunity" is a kind of...):

immunity; resistance ((medicine) the condition in which an organism can resist disease)

Hyponyms (each of the following is a kind of "innate immunity"):

racial immunity (natural immunity shared by all members of a particular race)

Credits

Context examples:

TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

(Allogeneic Renal Cell Carcinoma Vaccine MGN1601, NCI Thesaurus)

When there is an abnormality in the expression of these clock genes, the body’s innate immunity can go into overdrive.

(New study sheds fresh light on the genetic mechanisms involved in sepsis, the leading cause of death in ICUs, University of Granada)

During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy.

(Chagas Disease Pathway, NCI Thesaurus/KEGG)

Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity.

(Complement and Coagulation Cascade, NCI Thesaurus/KEGG)

In these disorders, the primary role of innate immunity to detect and neutralize pathogens which the individual has not been previously exposed is decreased or ineffective.

(Congenital Disorder of Natural Immunity, NCI Thesaurus)

An Antiinflammatory Effect involves interference with, or restraint of, local events that constitute part of innate immunity, involve increased blood supply, and infiltration and activity of leukocytes at a site of injury or disease.

(Negative Regulation of Inflammatory Response Process, NCI Thesaurus)

MBL, a soluble pattern recognition receptor (PRR) collectin in the C-type lectin superfamily, is a plasma protein that plays an important role in innate immunity; MBL contains a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other.

(Mannose-Binding Lectin, NCI Thesaurus)

A part of innate immunity, the Inflammatory Response occurs when injured tissues induce release of vasodilatory, opsonizing, and chemotactic mediators that attract macrophages and leukocytes to phagocytize and destroy foreign substances; dilate local blood vessels increasing local blood flow; increase capillary permeability; produce edematous swelling; and induce pain.

(Inflammatory Response, NCI Thesaurus)

CpG-28 has immunomodulatory properties with direct activation of B-lymphocytes, dendritic and NK cells resulting in the stimulation of innate immunity and antibody-dependant cell cytotoxicity (ADCC).

(CpG-28 Oligodeoxynucleotide, NCI Thesaurus)