| / English Dictionary |
INOSITOL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An optically inactive alcohol that is a component of the vitamin B complex
Classified under:
Hypernyms ("inositol" is a kind of...):
B; B-complex vitamin; B complex; B vitamin; vitamin B; vitamin B complex (originally thought to be a single vitamin but now separated into several B vitamins)
Context examples:
Also called inositol hexaphosphate and IP6.
(Phytic acid, NCI Dictionary)
A molecular genetic abnormality indicating the presence of a mutation in the PI3KCA (phosphatidyl inositol 3-kinase) gene on chromosome 3q26.32.
(PI3KCA Gene Mutation, NCI Thesaurus)
This gene plays a role in the synthesis of glycophosphatidyl inositol anchors.
(PIGF Gene, NCI Thesaurus)
A molecular genetic abnormality indicating the presence of multiple copies of the PIK3CA (phosphatidyl inositol 3-kinase) gene.
(PIK3CA Gene Amplification, NCI Thesaurus)
Phospholipase C (PLC) d1 is a member of the PLC family that produces two second messengers, diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) by hydrolyzing the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).
(Phospholipid Associated Cell Signaling Pathway, NCI Thesaurus/BIOCARTA)
Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3).
(Phospholipase C Signaling Pathway, NCI Thesaurus/BIOCARTA)
This protein plays a role in the first step of inositol-1,4,5,-trisphosphate production.
(Phosphatidylinositol 4-Kinase Beta, NCI Thesaurus)
This protein plays a role in glycophosphatidyl inositol anchor biosynthesis.
(Phosphatidylinositol-Glycan Biosynthesis Class F Protein, NCI Thesaurus)
Nine currently identified phosphoinositide 3-kinases (PI 3-K) constitute a subfamily of lipid kinases that catalyze the addition of a phosphate molecule on the 3-position of the inositol ring of phosphoinositides.
(Phosphoinositide Pathway, NCI Thesaurus/BIOCARTA)
Inositol 1,4,5-trisphosphate acts as an intermediate in the IP3/DAG pathway, hydrolyzed by phospholipase C and liberating diacylglycerol and PIP2, which activate Protein Kinase C and calcium release from the endoplasmic reticulum, respectively.
(Inositol 1,4,5-Trisphosphate, NCI Thesaurus)
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