| / English Dictionary |
INTERFERON
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus
Classified under:
Nouns denoting man-made objects
Hypernyms ("interferon" is a kind of...):
antiviral; antiviral agent; antiviral drug (any drug that destroys viruses)
Hyponyms (each of the following is a kind of "interferon"):
alpha-interferon (a form of interferon that is produced endogenously and commercially for its pharmacological effects (including regulation of the immune system and antiviral and antineoplastic effects))
beta-interferon (a form of interferon that is produced by fibroblasts and have antiviral effects; used in the treatment of multiple sclerosis)
gamma-interferon (a form of interferon that is produced by T cells and macrophages; involved in the activation of phagocytes)
Context examples:
Upon subcutaneous administration, IFN-a2b binds to specific interferon cell-surface receptors.
(PEG-Proline-Interferon Alfa-2b, NCI Thesaurus)
Although the mechanism of its anti-tumor activity is unclear, immunization with BCG (Bacillus Calmette-Guerin) likely activates a Th1 cytokine response that includes induction of interferon.
(BCG, NCI Thesaurus)
Coriolus versicolor extract has been shown to stimulate the production of lymphocytes and cytokines, such as interferons and interleukins, and may exhibit antioxidant activities.
(Coriolus versicolor extract, NCI Thesaurus)
TMEM173 encodes a protein called stimulator of interferon genes (STING).
(Gene linked to rare inflammatory disease in children, NIH)
This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
(Atorvastatin, NCI Thesaurus)
Similarly, the NIH researchers found that mutant MDA5 in the girl’s respiratory tissues could not recognize HRVs, preventing her immune system from producing protective signaling proteins called interferons.
(Scientists discover rare genetic susceptibility to common cold, National Institutes of Health)
Both type 1 interferon (IFN) signaling and interferon regulatory factor 1 (IRF1) expression increased.
(Virus linked to food sensitivity, NIH)
The study also shows that neurons infected by LACV can be rescued by interferon, a powerful antiviral protein.
(Cerebral organoid model provides clues about how to prevent virus-induced brain cell death, National Institutes of Health)
Evaluation of host cellular gene expression in mice treated with glutamine showed that several genes inducible by interferon gamma (IFN-γ) had an increased response.
(Glutamine suppresses herpes in mice and guinea pigs, National Institutes of Health)
A long-acting, recombinant fusion polypeptide consisting of interferon alpha-2b (IFNa-2b) linked to human albumin (alb-IFN), with antiviral and immunomodulatory activity.
(Albinterferon Alfa-2b, NCI Thesaurus)
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