/ English Dictionary

INTERNALIZE

Pronunciation (US):

(GB):

 I. (verb) 

Sense 1

Meaning:

Incorporate within oneself; make subjective or personal

Example:

internalize a belief

Synonyms:

interiorise; interiorize; internalise; internalize

Classified under:

Verbs of thinking, judging, analyzing, doubting

Hypernyms (to "internalize" is one way to...):

ascribe; assign; attribute; impute (attribute or credit to)

Domain category:

psychological science; psychology (the science of mental life)

Sentence frames:

Somebody ----s something
Somebody ----s something PP

Derivation:

internalization (learning (of values or attitudes etc.) that is incorporated within yourself)

Credits

 Context examples: 

Upon intravenous administration of ADC AGS-16C3F, the monoclonal antibody moiety of this conjugate selectively binds to ENPP3 then is internalized and undergoes proteolytic cleavage to release MMAF.

(Anti-ENPP3 Antibody-Drug Conjugate AGS-16C3F, NCI Thesaurus)

Once internalized, GPCRs exhibit two distinct patterns of b-arrestin interaction.

(GPCR Desensitization Pathway, NCI Thesaurus/BIOCARTA)

Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2).

(Moxetumomab Pasudotox, NCI Thesaurus)

To transmit the signal back along the axon, activated Trk receptors are internalized through receptor-mediated endocytosis and receptor containing vesicles then rapidly travel back to the cell body along axonal microtubules.

(Neuronal Survival Pathway, NCI Thesaurus/BIOCARTA)

Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation.

(Iodine I 125-Anti-EGFR-425 Monoclonal Antibody, NCI Thesaurus)

The endosomal compartment that fuses with endocytic vesicles and sorts the plasma membrane components from any internalized molecules that are targeted for lysosomal degradation.

(Early Endosome, NCI Thesaurus)

Once internalized, receptors can either be degraded in lysosomes or they can be recycled back to the cell surface.

(Attenuation of GPCR Signaling Pathway, NCI Thesaurus/BIOCARTA)

Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis.

(botulinum toxin type A, NCI Thesaurus)

If the B cell receptor immunoglobulin binds specific antigen, then the cell internalizes the antigen and presents it to T cells in MHC II, where it is recognized by the T cell receptor.

(Antigen Dependent B Cell Activation Pathway, NCI Thesaurus/BIOCARTA)

Amcinonide interacts with specific corticosteroid receptors and was internalized, which leads to binding of DNA and modification of gene expression.

(Amcinonide, NCI Thesaurus)

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