| / English Dictionary |
IRREVERSIBLY
| Pronunciation (US): |  | (GB): | |
I. (adverb)
Sense 1
Meaning:
In an irreversible manner
Example:
this old tradition is irreversibly disappearing
Classified under:
Pertainym:
irreversible (incapable of being reversed)
Context examples:
Neomycin sulfate, an aminoglycoside antibiotic, irreversibly binds to the bacterial 30S ribosomal subunit, thereby preventing mRNA from binding to the 30S subunit, causes misreading and inhibits protein synthesis.
(Neosporin Cream, NCI Thesaurus)
Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit.
(Neomycin, NCI Thesaurus)
Dacomitinib specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.
(Dacomitinib, NCI Thesaurus)
Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
(Exemestane, NCI Thesaurus)
Atamestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
(Atamestane, NCI Thesaurus)
PF-00299804 specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors.
(Carbon C-14 Dacomitinib, NCI Thesaurus)
Bekanamycin irreversibly binds to the bacterial 30S ribosomal subunit.
(Bekanamycin, NCI Thesaurus)
Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation.
(Canertinib dihydrochloride, NCI Thesaurus)
By irreversibly inhibiting BTK, administration of this agent may lead to an inhibition of B cell receptor (BCR) signaling and may inhibit cell proliferation of B-cell malignancies.
(BTK Inhibitor CC-292, NCI Thesaurus)
Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit.
(Amikacin Sulfate, NCI Thesaurus)
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