| / English Dictionary |
LDL
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A lipoprotein that transports cholesterol in the blood; composed of moderate amount of protein and a large amount of cholesterol; high levels are thought to be associated with increased risk of coronary heart disease and atherosclerosis
Synonyms:
beta-lipoprotein; LDL; low-density lipoprotein
Classified under:
Hypernyms ("LDL" is a kind of...):
lipoprotein (a conjugated protein having a lipid component; the principal means for transporting lipids in the blood)
Meronyms (substance of "LDL"):
LDL cholesterol (the cholesterol in low-density lipoproteins; the 'bad' cholesterol; a high level in the blood is thought to be related to various pathogenic conditions)
Context examples:
The study has important implications for the development of new drugs that may prevent early CAVD from progressing to stenosis by making GAGs less likely to bind LDL.
(New Hope for Stopping An Understudied Heart Disease in Its Tracks, The Titi Tudorancea Bulletin)
The low-glycemic index/low-carbohydrate diet resulted in similar insulin sensitivity, systolic blood pressure and HDL and LDL cholesterol levels when compared to the high-glycemic index/high-carbohydrate diet.
(Low-glycemic diets may not improve cardiovascular outcomes when compared to high-glycemic diets, NIH)
These participants had 39% lower triglyceride levels, 22% higher HDL cholesterol levels, 16% lower LDL cholesterol levels, and 46% lower circulating APOC3 levels compared to participants who did not have any of these genetic misspellings.
(Rare mutations reduce heart disease risk, NIH)
Bezafibrate decreases triglyceride levels, increases high density lipoprotein (HDL) cholesterol levels, and decreases total and low density lipoprotein (LDL) cholesterol levels.
(Bezafibrate, NCI Thesaurus)
Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles.
(Atorvastatin, NCI Thesaurus)
Also called: HDL, LDL, Hyperlipidemia, Hypercholesterolemia, Familial Hypercholesterolemia, Familial Combined Hyperlipidemia, Hyperlipoproteinemia
(Cholesterol, NIH: National Heart, Lung, and Blood Institute)
In Phase II trials canosimibe reduced LDL cholesterol levels, but it did not demonstrate the desired efficacy in a Phase III study, and was discontinued.
(Canosimibe, NCI Thesaurus)
This agent helps reduce LDL cholesterol and triglyceride levels, and is not associated with weight gain, and prevents the cardiovascular complications of diabetes.
(Metformin, NCI Thesaurus)
Activation of LDL by ibrolipim lowers plasma triglycerides, with a concomitant elevation of high-density lipoprotein cholesterol.
(Ibrolipim, NCI Thesaurus)
A relative measurement (ratio or percentage) of the amount of HDL cholesterol compared to LDL cholesterol in a biological specimen.
(HDL Cholesterol to LDL Cholesterol Ratio Measurement, NCI Thesaurus/CDISC)
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