| / English Dictionary |
LECTIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Any of several plant glycoproteins that act like specific antibodies but are not antibodies in that they are not evoked by an antigenic stimulus
Classified under:
Hypernyms ("lectin" is a kind of...):
glycoprotein (a conjugated protein having a carbohydrate component)
Context examples:
E-Selectin exhibits homologous structural features to L-selectin, including lectin- and EGF-like domains followed by SCR domains.
(E-Selectin, NCI Thesaurus)
There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway.
(Complement and Coagulation Cascade, NCI Thesaurus/KEGG)
Several amoebic proteins such as lectins, cysteine proteinases, and amoebapores are associated with the invasion process.
(Amoebiasis Pathway, NCI Thesaurus/KEGG)
Any physiologic process in which a protease directs the cleavage of complement components C4, C2, or factor B which then form the C3 and C5 convertases for the classical and lectin pathways, respectively.
(Complement Activation, NCI Thesaurus)
A mannose-binding lectin originally isolated from jack-bean, Canavalia ensiformis.
(Concanavalin A, NCI Thesaurus)
Apoptosis inducer GCS-100 binds to the carbohydrate-binding domain of the lectin galectin-3, which may result in apoptosis mediated through mitochondria/caspase activation cascades; this agent may overcome tumor growth mediated through anti-apoptotic protein Bcl-2, heat-shock protein 27 (Hsp27), and nuclear factor-kappa B (NF-kB).
(Apoptosis Inducer GCS-100, NCI Thesaurus)
Blocked ricin is ricin which has been chemically modified such that the lectin binding sites of the B chain (galactose-binding sites) have been blocked by covalent attachment of affinity ligands, leaving the ribosome-inactivating activity of the ricin A chain intact.
(Anti-B4 Blocked Ricin Immunotoxin, NCI Thesaurus)
The beta-glucan in beta-glucan MM-10-001 binds to a lectin site within the complement receptor 3 (CR3 or iC3b receptor) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to iC3b-opsonized tumor cells. iC3b is the proteolyticly inactive product of the complement cleavage fragment C3b.
(Beta-Glucan MM-10-001, NCI Thesaurus)
Productive folding of the polypeptides to which the glycans are attached requires the services of an ER lectin chaperone called calnexin (CNX) that recognize the Glc1Man9GlcNAc2 oligosaccharide and assists the folding of newly synthesized glycoproteins.
(Endoplasmic Reticulum Degradation Pathway, NCI Thesaurus/BIOCARTA)
In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors.
(Beta-glucan, NCI Thesaurus)
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