| / English Dictionary |
LIGAND
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A substance (an atom or molecule or radical or ion) that forms a complex around a central atom
Classified under:
Hypernyms ("ligand" is a kind of...):
substance (a particular kind or species of matter with uniform properties)
II. (verb)
Sense 1
Present simple (first person singular and plural, second person singular and plural, third person plural) of the verb ligand
Context examples:
A ligand for ERBB4 receptor tyrosine kinase (likely via the EGF-like domain), NRG3 does not bind to ERBB2, ERBB3, or EGF receptor.
(Neuregulin 3, NCI Thesaurus)
Neuregulin-1 was first cloned as "heregulin" and "neu differentiation factor" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer.
(Neuregulin 1, NCI Thesaurus)
NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing.
(Neuro-Oncological Ventral Antigen 2, NCI Thesaurus)
This allele, which encodes activin receptor type 2B protein, plays a role in ligand binding interactions pertaining to TGF-beta signal transduction.
(ACVR2B wt Allele, NCI Thesaurus)
It is a ligand for the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor.
(Neuregulin 1, NLM, Medical Subject Headings)
This receptor binds ligands such as hormones, antigens, drugs, or neurotransmitters.
(Neural Peptide Receptor, NCI Thesaurus)
Any intercellular signaling process that reduces the frequency or extent of binding of a cognate ligand to an intracellular or transmembrane receptor to initiate an intracellular response.
(Negative Regulation of Receptor Activation, NCI Thesaurus)
Any physiologic process which occurs in response to ligation of an immunologic factor receptor with its cognate ligand, and results in a reduced number of active signaling molecules within the target cell.
(Negative Regulation of Immunologic Factor Signaling, NCI Thesaurus)
A water-soluble, positively charged fusion protein consisting of a luteinizing hormone releasing hormone (LHRH) receptor-targeting ligand conjugated to the membrane-disrupting peptide CLIP 71 with membrane-disrupting and potential antineoplastic activities.
(Membrane-Disrupting Peptide EP-100, NCI Thesaurus)
Metastin is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis.
(Metastin, NCI Thesaurus)
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